Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Special Issue "The Outcome of Sepsis"
A special issue of Healthcare (ISSN 2227-9032).
Deadline for manuscript submissions: closed (31 October 2018).
Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, United States
Interests: sepsis; outcome; recovery; epigenetic; post-ICU syndrome; extra-corporeal membrane oxygenation; immunoparalysis; anergy; behavioral economic; medical decision making; intensive care; medicine in austere settings
Sepsis remains a significant health problem worldwide. Unsurprisingly, sepsis and long-term related post-sepsis syndromes have profound clinical, societal, and economic significance to both individual patients and society. Despite its importance, this is an under-investigated area of research, with the majority studies focusing on early response and treatment. It was previously believed that the host’s body returns to pre-insult homeostasis after sepsis, but Medzhitov et al. suggested that a new immunological state emerges post-sepsis, one which could have a detrimental clinical effect. Evidence demonstrates that the initial insult alters the immune system and determines its responses to subsequent challenges for an extended period. The abnormal response to subsequent challenges is the reason why some patients are prone to progressive organ failures, hastened atherosclerosis, the resurgence of opportunistic infections, and a decline in cognitive functioning in the months or years after the initial insult. This is of utmost significance for patients’ long-term health. Concomitantly, patient’s family are enveloped in their predicament. Taken together, the aftermath of sepsis is often long-term the healthcare-related expenses continue to rise despite some progress in tackling the early mortality. It remains to be described how medical therapy, physical therapy, and medical decision making can result in improve recovery after sepsis and lower the medical expenses.
Dr. Krzysztof Laudanski
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- post-ICU syndrome