Special Issue "Radiotherapy and Cancer"

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Dr. Andrew Hartley

Hall-Edwards Radiotherapy Research Group, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
Website | E-Mail
Interests: radiobiological models, oropharyngeal cancer trials, mucositis

Special Issue Information

Dear Colleagues,

Radiotherapy for cancer is rapidly evolving: the use of protons with the aim of sparing acute and late radiation toxicity and reducing second malignancies is becoming more widespread; interest in the potential use of other ions is increasing; stereotactic ablative body radiotherapy is being widely used as an alternative to surgery or to delay the initiation of palliative systemic chemotherapy; combinations of precision surgery and lower dose radiotherapy are being examined in randomized trials; immunotherapy is being tested in combination with radiotherapy; there is a renewed emphasis on both contour peer review and more detailed guidelines for clinical target volume definition. The purpose of this Special Issue is to examine these and other developments in radiotherapy.

Dr. Andrew Hartley
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Radiation Toxicity
  • Protons
  • Heavy Ions
  • SABR (stereotactic ablative body radiotherapy)
  • Radiotherapy dose de-escalation
  • Immunotherapy
  • Peer review

Published Papers (1 paper)

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Research

Open AccessArticle
Assessment of the Impact of Deformable Registration of Diagnostic MRI to Planning CT on GTV Delineation for Radiotherapy for Oropharyngeal Carcinoma in Routine Clinical Practice
Healthcare 2018, 6(4), 135; https://doi.org/10.3390/healthcare6040135
Received: 24 October 2018 / Revised: 15 November 2018 / Accepted: 20 November 2018 / Published: 24 November 2018
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Abstract
Background: Aim of study was to assess impact of deformable registration of diagnostic MRI to planning CT upon gross tumour volume (GTV) delineation of oropharyngeal carcinoma in routine practice. Methods: 22 consecutive patients with oropharyngeal squamous cell carcinoma treated with definitive (chemo)radiotherapy between [...] Read more.
Background: Aim of study was to assess impact of deformable registration of diagnostic MRI to planning CT upon gross tumour volume (GTV) delineation of oropharyngeal carcinoma in routine practice. Methods: 22 consecutive patients with oropharyngeal squamous cell carcinoma treated with definitive (chemo)radiotherapy between 2015 and 2016, for whom primary GTV delineation had been performed by a single radiation oncologist using deformable registration of diagnostic MRI to planning CT, were identified. Separate GTVs were delineated as part of routine clinical practice (all diagnostic imaging available side-by-side for each delineation) using: CT (GTVCT), MRI (GTVMR), and CT and MRI (GTVCTMR). Volumetric and positional metric analyses were undertaken using contour comparison metrics (Dice conformity index, centre of gravity distance, mean distance to conformity). Results: Median GTV volumes were 13.7 cm3 (range 3.5–41.7), 15.9 cm3 (range 1.6–38.3), 19.9 cm3 (range 5.5–44.5) for GTVCT, GTVMR and GTVCTMR respectively. There was no significant difference in GTVCT and GTVMR volumes; GTVCTMR was found to be significantly larger than both GTVMR and GTVCT. Based on positional metrics, GTVCT and GTVMR were the least similar (mean Dice similarity coefficient (DSC) 0.71, 0.84, 0.82 for GTVCT–GTVMR, GTVCTMR–GTVCT and GTVCTMR–GTVMR respectively). Conclusions: These data suggest a complementary role of MRI to CT to reduce the risk of geographical misses, although they highlight the potential for larger target volumes and hence toxicity. Full article
(This article belongs to the Special Issue Radiotherapy and Cancer)
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