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Assessment of the Impact of Deformable Registration of Diagnostic MRI to Planning CT on GTV Delineation for Radiotherapy for Oropharyngeal Carcinoma in Routine Clinical Practice

1
School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
2
Department of Clinical Oncology, St. James’s University Hospital, Leeds Cancer Centre, Beckett Street, Leeds LS9 7TF, UK
*
Author to whom correspondence should be addressed.
Healthcare 2018, 6(4), 135; https://doi.org/10.3390/healthcare6040135
Received: 24 October 2018 / Revised: 15 November 2018 / Accepted: 20 November 2018 / Published: 24 November 2018
(This article belongs to the Special Issue Radiotherapy and Cancer)
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Abstract

Background: Aim of study was to assess impact of deformable registration of diagnostic MRI to planning CT upon gross tumour volume (GTV) delineation of oropharyngeal carcinoma in routine practice. Methods: 22 consecutive patients with oropharyngeal squamous cell carcinoma treated with definitive (chemo)radiotherapy between 2015 and 2016, for whom primary GTV delineation had been performed by a single radiation oncologist using deformable registration of diagnostic MRI to planning CT, were identified. Separate GTVs were delineated as part of routine clinical practice (all diagnostic imaging available side-by-side for each delineation) using: CT (GTVCT), MRI (GTVMR), and CT and MRI (GTVCTMR). Volumetric and positional metric analyses were undertaken using contour comparison metrics (Dice conformity index, centre of gravity distance, mean distance to conformity). Results: Median GTV volumes were 13.7 cm3 (range 3.5–41.7), 15.9 cm3 (range 1.6–38.3), 19.9 cm3 (range 5.5–44.5) for GTVCT, GTVMR and GTVCTMR respectively. There was no significant difference in GTVCT and GTVMR volumes; GTVCTMR was found to be significantly larger than both GTVMR and GTVCT. Based on positional metrics, GTVCT and GTVMR were the least similar (mean Dice similarity coefficient (DSC) 0.71, 0.84, 0.82 for GTVCT–GTVMR, GTVCTMR–GTVCT and GTVCTMR–GTVMR respectively). Conclusions: These data suggest a complementary role of MRI to CT to reduce the risk of geographical misses, although they highlight the potential for larger target volumes and hence toxicity. View Full-Text
Keywords: radiotherapy; deformable image registration; magnetic resonance imaging; oropharyngeal squamous cell carcinoma; gross tumour volume radiotherapy; deformable image registration; magnetic resonance imaging; oropharyngeal squamous cell carcinoma; gross tumour volume
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Taylor, A.; Sen, M.; Prestwich, R.J.D. Assessment of the Impact of Deformable Registration of Diagnostic MRI to Planning CT on GTV Delineation for Radiotherapy for Oropharyngeal Carcinoma in Routine Clinical Practice. Healthcare 2018, 6, 135.

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