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Research Advances in Gastroenterology
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Research Advances in Gastroenterology

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (16 January 2024) | Viewed by 7193

Special Issue Editor

Dr. Richard You Wu

E-Mail Website
Guest Editor
1. Cell Biology Program, Research Institute Hospital for Sick Children, Toronto, ON M5G 0A4, Canada
2. Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada
3. Department of Medicine, University of Toronto, Toronto, ON, Canada
Interests: probiotics; prebiotics; postbiotics; reflex; food microbiology; bacteriocins; synbiotics; IBS; IBD; gut microbiome; infectious diseases

Special Issue Information

Dear Colleagues,

The current advancements in basic sciences, systems biology and modern technology have reshaped the way that clinicians think about modern diseases. One field particularly impacted by the progressive intersections of cell biology, microbiology, immunology, systems biology and modern technologies is clinical gastroenterology. Yet, despite these new ideas, the translational utility of emerging technologies in transforming care in gastroenterology are often overlooked.

This current Special Issue is soliciting manuscripts addressing topics relating to emerging technologies related to the diagnosis, prognosis, and treatment of diseases or the management of social factors relating to patient understanding, perception and/or awareness of gastrointestinal disorders. Original articles, reviews and perspectives on these translational technologies are encouraged. Given the intersection of multiple areas, manuscripts focused on translational research in biology, immunology, microbiology, systems biology, social sciences as well as qualitative pieces are strongly encouraged. In particular, studies relating to the use of social media and modern technological systems are welcome.

The aim of this Special Issue is to provide a special collection on the emerging technologies that influence the field of gastroenterology, with particular focus on biological, social and epidemiological approaches.

Dr. Richard You Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • metabolomics
  • biologics
  • mucosal immunology
  • personalized medicine
  • organoids
  • healthcare delivery
  • mobile apps
  • telemedicine
  • virtual care
  • patient knowledge and perception
  • social determinants of health

Published Papers (2 papers)

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Research

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14 pages, 1017 KiB  
Article
Health-Related Quality of Life and Stress-Related Disorders in Patients with Complicated Diverticular Disease under Conservative Management
by Tudor Mateescu, Bogdan Miutescu, Alin Nicola, Cristian Oancea, Paula Irina Barata, Cristi Tarta, Lazar Fulger and Cristian Paleru
Healthcare 2023, 11(10), 1383; https://doi.org/10.3390/healthcare11101383 - 10 May 2023
Cited by 1 | Viewed by 1256
Abstract
Diverticular disease is a common gastrointestinal disorder with increasing prevalence in advanced age. This study aimed to investigate the impact of age and complexity of diverticulitis on health-related quality of life (HRQoL) and stress-related disorders. A cross-sectional study was conducted on 180 patients, [...] Read more.
Diverticular disease is a common gastrointestinal disorder with increasing prevalence in advanced age. This study aimed to investigate the impact of age and complexity of diverticulitis on health-related quality of life (HRQoL) and stress-related disorders. A cross-sectional study was conducted on 180 patients, including adults (18–64 years) with complicated diverticular disease, the elderly (≥65 years) with complicated diverticular disease, and a control group with uncomplicated symptomatic diverticular disease. HRQoL and stress-related disorders were assessed using the SF-36, GIQLI, HADS, and PHQ-9 questionnaires at baseline and six months after the initial episode of diverticulitis. At diagnosis, the adult group had significantly lower mean physical and mental scores compared with the elderly and control groups (p < 0.001). At the 6-month follow-up, the mean physical score increased for all groups, but the difference between adults and the elderly remained significant (p = 0.028). The adult group had a significantly lower mean GIQLI score at diagnosis compared with the elderly and control groups (p < 0.001), although after 6 months it increased and the difference became insignificant. Anxiety scores at diagnosis were significantly higher in the adult group compared with the control group (p = 0.009). The complexity of diverticulitis and age significantly impacted HRQoL at diagnosis, with adults having lower physical and mental scores compared with elderly patients and controls. Although improvements were observed after 6 months, the difference between adults and the elderly remained significant for physical HRQoL scores. This highlights the need for tailored management strategies and psychosocial support to optimize patient outcomes across age groups and diverticulitis complexity. Full article
(This article belongs to the Special Issue Research Advances in Gastroenterology)
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10 pages, 662 KiB  
Review
Probiotics for the Prevention of Antibiotic-Associated Diarrhea
by Kira Kopacz and Sangita Phadtare
Healthcare 2022, 10(8), 1450; https://doi.org/10.3390/healthcare10081450 - 2 Aug 2022
Cited by 16 | Viewed by 5270
Abstract
Several communities have started using probiotic-rich fermented foods as therapeutic options with presumed medicinal powers. We now know the importance of microbiome balance and how probiotics can restore imbalances in the microbiome. Probiotics have been tested for a number of clinical uses such [...] Read more.
Several communities have started using probiotic-rich fermented foods as therapeutic options with presumed medicinal powers. We now know the importance of microbiome balance and how probiotics can restore imbalances in the microbiome. Probiotics have been tested for a number of clinical uses such as the prevention of antibiotic-associated diarrhea (AAD), the treatment of various diseases such as H. pylori infection, irritable bowel disease, vaginitis, the prevention of allergies, and necrotizing enterocolitis in newborns. AAD has been the most indicated therapeutic use for probiotics. AAD is a common side effect of antibiotic usage, which affects up to 30% of patients. The hypothesis behind using probiotics for AAD is that they help normalize an unbalanced flora. There are many potential mechanisms by which probiotics support intestinal health such as (i) boosting immunity, (ii) increasing gut barrier integrity, (iii) producing antimicrobial substances, (iv) modulating the gut microbiome, (v) increasing water absorption, and (vi) decreasing opportunistic pathogens. Many randomized-controlled trials including the strain-specific trials that use Lactobacillus and Saccharomyces and meta-analyses have shown the benefits of probiotics in addressing AAD. Although adverse events have been reported for probiotics, these are broadly considered to be a safe and inexpensive preventative treatment option for AAD and other gastrointestinal disorders. Full article
(This article belongs to the Special Issue Research Advances in Gastroenterology)
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