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Healthcare
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Cutting-Edge Approaches in Neurological Disease Treatment
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Cutting-Edge Approaches in Neurological Disease Treatment

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1805

Special Issue Editors

Dr. José Alberto Frade Martins Parraca

E-Mail Website
Guest Editor
1. Departamento de Desporto e Saúde, Escola de Saúde e Desenvolvimento Humano, Universidade de Évora, 7004-516 Evora, Portugal
2. Comprehensive Health Research Centre (CHRC), Universidade de Évora, 7004-516 Evora, Portugal
Interests: physiology; exercise; prevention; elderly
Special Issues, Collections and Topics in MDPI journals
Dr. Alejandro Rubio-Zarapuz

E-Mail Website
Guest Editor Assistant
Faculty of Sport Sciences, European University of Madrid, 28670 Villaviciosa de Odón, Spain
Interests: nutrition; physical activity; exercise science; exercise physiology; sports science; athletic performance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue highlights recent clinical advancements in the treatment of neurological diseases, focusing on approaches that enhance patient care and improve health outcomes. Neurological diseases, such as Alzheimer's, Parkinson's, multiple sclerosis, and fibromyalgia, affect millions worldwide, contributing to significant disability and healthcare challenges. This Special Issue will emphasize innovations in diagnostic tools that allow for earlier and more precise detection of these conditions, as well as new therapeutic interventions that are directly applicable in clinical practice. Topics include advanced imaging methods, improved clinical management strategies, and non-invasive neuromodulation techniques like transcranial magnetic stimulation that are showing promise in routine care. By gathering insights from leading clinicians and healthcare experts, this Special Issue aims to provide an up-to-date perspective on practical approaches for managing neurological diseases, discuss emerging clinical trends, and outline future directions for optimizing patient outcomes. The overarching goal is to enhance the quality of life for patients and improve the efficacy of current treatment strategies.

Dr. José Alberto Frade Martins Parraca
Guest Editor

Dr. Alejandro Rubio-Zarapuz
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurological disease treatment
  • clinical management of neurodegenerative disorders
  • patient care strategies
  • non-invasive neuromodulation
  • advanced imaging in clinical settings
  • health outcomes in neurological care

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Published Papers (2 papers)

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13 pages, 294 KB  
Article
Gait and Dual-Task Performance in Older Adults with Suspected Cognitive Impairment: Effects of an 8-Week Exercise Program
by João Galrinho, Marco Batista, Marta Gonçalves-Montera, Orlando Fernandes and Ana Rita Matias
Healthcare 2025, 13(24), 3190; https://doi.org/10.3390/healthcare13243190 - 5 Dec 2025
Viewed by 962
Abstract
Background/Objectives: Gait performance in aging relies heavily on cognitive resources, yet the extent to which short-term interventions can mitigate dual-task costs in institutionalized populations remains understudied. This study aimed to compare single and dual-task gait performance between older adults with and without suspected [...] Read more.
Background/Objectives: Gait performance in aging relies heavily on cognitive resources, yet the extent to which short-term interventions can mitigate dual-task costs in institutionalized populations remains understudied. This study aimed to compare single and dual-task gait performance between older adults with and without suspected cognitive impairment and to evaluate the effects of an 8-week multicomponent exercise program on functional mobility. Methods: Institutionalized older adults (n = 42) were stratified into two groups: suspected cognitive impairment (n = 26) and no suspected impairment (n = 16), based on MMSE and Clock Drawing Test screening. Participants performed the Timed Up and Go (TUG) and Dual-Task TUG (TUG-DT) at baseline and post-intervention. Results: At baseline, the suspected impairment group exhibited significantly poorer performance on both tests (p < 0.001) compared to the non-impaired group. Following the 8-week intervention, the suspected impairment group demonstrated large, significant improvements in both TUG (r = −0.73) and TUG-DT (r = −0.59), whereas the non-impaired group remained stable. Notably, while the single-task TUG showed the greatest responsiveness to the exercise program, the TUG-DT continued to reveal a significant cognitive-motor load. Conclusions: Multicomponent exercise effectively enhances functional mobility in cognitively vulnerable older adults, reversing declines in both single and dual-task conditions. Significance: These findings support the implementation of dual-task screening to unmask latent functional deficits and validate the use of accessible, short-term multicomponent exercise programs as a vital strategy to preserve autonomy in institutionalized older adults. Full article
(This article belongs to the Special Issue Cutting-Edge Approaches in Neurological Disease Treatment)

Other

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8 pages, 420 KB  
Case Report
Novel Application of Transcutaneous Electrical Stimulation for Ophthalmoplegia in Miller Fisher Syndrome: A Case Report
by Ying-Chi Huang and Fred Yi-Shueh Chen
Healthcare 2025, 13(23), 3154; https://doi.org/10.3390/healthcare13233154 - 3 Dec 2025
Viewed by 480
Abstract
We report the case of a 62-year-old woman with Miller Fisher syndrome (MFS) whose severe bilateral ophthalmoplegia showed no improvement after four weeks of standard care consisting of intravenous immunoglobulin and physiotherapy. High-frequency transcutaneous electrical nerve stimulation (TENS) was applied over the bilateral [...] Read more.
We report the case of a 62-year-old woman with Miller Fisher syndrome (MFS) whose severe bilateral ophthalmoplegia showed no improvement after four weeks of standard care consisting of intravenous immunoglobulin and physiotherapy. High-frequency transcutaneous electrical nerve stimulation (TENS) was applied over the bilateral sternocleidomastoid muscles and immediately followed by eye-movement exercises. Within three days, ocular motility began to improve, and after one month, only minimal left-eye abduction lag remained. Such neuromodulation of TENS might act on central and peripheral tiers of the oculomotor system and may have been temporally associated with faster recovery than expected in the natural course of the disease compared to the median three-month interval. This dramatic, time-associated improvement highlights the novelty of cervical TENS as a potential accelerator for recovery in MFS-related ophthalmoplegia. To the best of our knowledge, research involving the use of TENS in MFS-related ophthalmoplegia is limited, and our case demonstrates the feasibility and safety of TENS for faster recovery. Full article
(This article belongs to the Special Issue Cutting-Edge Approaches in Neurological Disease Treatment)
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