Genetics and Epigenetics of Cellular Differentiation
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".
Deadline for manuscript submissions: 25 March 2026 | Viewed by 818
Special Issue Editor
2. The Francis Crick Institute, London, UK
Interests: RNA biology; N6-methyladenosine; epitranscriptomics; mRNA decay; hypoxia; cancer; translation; stress response; stem cells; differentiation; gene expression; genetics; histone modifications; DNA methylation
Special Issue Information
Dear Colleagues,
Unspecialized cells like stem cells are characterized by their ability to differentiate into different cell types. These processes are determined by genetics, gene expression signatures, and epigenetics, but the mechanisms are not fully characterized. First of all, certain genes are active and inactive, and this can be partially controlled by transcription factors. Different transcription factors can be active and repressed amongst cell types. Epigenetic mechanisms such as histone modifications, including acetylation and methylation, chromatin remodelling, DNA methylation, and non-coding RNA-mediated regulation represent another layer of regulation. In this Special Issue, we aim to uncover novel knowledge on the genetic and epigenetic mechanisms that control cell differentiation. Understanding how stem cells give rise to mature cells will result in effective stem-cell-based therapies.
Dr. Theodora Sideri
Guest Editor
Manuscript Submission Information
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Keywords
- stem cells
- differentiation
- gene expression
- genetics
- histone modifications
- DNA methylation
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