Preclinical and Clinical Genetics in Parkinson’s Disease
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 44340
Special Issue Editors
Interests: neurology; neuroscience; Parkinson's disease; dementia; clinical neuroscience; nervous system damage; signal transduction
Special Issue Information
After a decade of unsuccessful testing of drugs in clinical trials, which were supposed to prevent, hold, or cure Parkinson’s disease, the focus switched back to investigating the molecular causes and mechanisms leading to this devastating disease. The lack of knowledge about the detailed mechanism of the disease’s cause and progression seems to have hampered the development of successful clinical trials’ design, execution, and interpretation.
Currently, 20 genes are associated with Parkinson’s disease and 90 independent risk-associated variants have been described (Blauwendraat et al., Lancet 2019). The proteins encoded by these genes and the associated risk factors form a network with a multitude of crosstalk events and interactions. Although age is the largest risk factor for Parkinson’s disease, one large, or several small, alterations can lead to a significant change in the network that over time can cause the slow progressive degeneration of substantia nigra dopaminergic neurons and other cells in the brain.
This Special Issue will focus on work that highlights the current knowledge and the ongoing research in the field of Parkinson’s disease genetics and genetic Parkinson’s disease animal models in the clinical and preclinical setting. We are encouraging colleagues with experience in this topic to provide original research articles, reviews and short communications (data and news and views).
Dr. Olga Corti
Dr. Edgar Kramer
Dr. Jaan-Olle Andressoo
Guest Editors
Manuscript Submission Information
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Keywords
- Parkinson’s disease (PD)
- Genetics of PD
- Midbrain dopaminergic neurons
- Animal models of PD
- Clinical trials for PD
- Genome-wide association studies (GWAS) for PD
- Molecular signalling in PD
- PD-associated protein networks
- Crosstalk of PD linked proteins, RNAs, lipids, and chemicals
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