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Special Issue "Genetics of Leishmania"
Deadline for manuscript submissions: closed (30 August 2019).
Interests: taxonomy, phylogeny and population genetics of Leishmania genus, detection of inter- and intraspecific variation between leishmanial parasites
Genes is announcing a Special Issue on “Genetics of Leishmania” for 2019, which will be open for studies on different aspects of genomics, genetics, and gene research in Leishmania parasites.
Reference genomes have been published for many Leishmania species and are available on the kinetoplastid genome database, TriTrypDB, together with unpublished assemblies for other species and strains. Although consistent, high-quality automated annotation is now possible, manual inspection and improvement of annotation is still critical. Genome-wide approaches have, so far, proved their potential for improving Leishmania taxonomy and exploring the origin of the genus, and for studying the microevolution of leishmanial populations. A comparison of different leishmanial genomes revealed a remarkable conservation of gene content and synteny in orthologous chromosomes and confirmed the significance of variable aneuploidy in these parasites, which seems to be adaptive and to depend on their life stage. Exploring the extent of genomic diversity in species and strains of Leishmania in comparison with phenotypic variations will help one to better understand the interplay between parasites, vectors, and hosts, and for developing effective drug and immunotherapeutic interventions.
We invite publications from scientists using genomic or genetic smaller-scale genetic approaches, including bioinformatics, to detect variations in coding or non-coding regions of leishmanial genomes. We are also interested in studies investigating the relations between genotypic and phenotypic diversity. Finally, we encourage the publication of population genetic, phylogenomic, and phylogenetic studies for Leishmania.
Dr. Gabriele Schönian
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Leishmania genus
- Whole-genome sequencing
- Genomic diversity
- Bioinformatic tools
- Genetic variation
- Inter- and intraspecific variations
- Population genetic studies
- Phylogeny and phylogenomics
- Virulence determinants
- Drug resistance
- Immunogenic determinants
- Molecular epidemiology
- Parasite–host interplay