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Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis
Review

Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas

1
Laboratory of Research on Leishmaniasis, Oswaldo Cruz Institute, FIOCRUZ, 21040-360 Rio de Janeiro, Brazil
2
Department of Parasites and Insect Vectors, Laboratory of Molecular Parasitology and Signaling, Institut Pasteur, INSERN U1201, 75015 Paris, France
3
Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, 75015 Paris, France
4
Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, G128QQ Glasgow, UK
*
Author to whom correspondence should be addressed.
Received: 25 November 2019 / Revised: 13 December 2019 / Accepted: 17 December 2019 / Published: 19 December 2019
(This article belongs to the Special Issue Genetics of Leishmania)
Pathogen fitness landscapes change when transmission cycles establish in non-native environments or spill over into new vectors and hosts. The introduction of Leishmania infantum in the Americas into the Neotropics during European colonization represents a unique case study to investigate the mechanisms of ecological adaptation of this important parasite. Defining the evolutionary trajectories that drive L. infantum fitness in this new environment are of great public health importance as they will allow unique insight into pathways of host/pathogen co-evolution and their consequences for region-specific changes in disease manifestation. This review summarizes current knowledge on L. infantum genetic and phenotypic diversity in the Americas and its possible role in the unique epidemiology of visceral leishmaniasis (VL) in the New World. We highlight the importance of appreciating adaptive molecular mechanisms in L. infantum to understand the parasite’s successful establishment on the continent. View Full-Text
Keywords: Leishmania; visceral leishmaniasis; Americas; genome instability; adaptation Leishmania; visceral leishmaniasis; Americas; genome instability; adaptation
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MDPI and ACS Style

Boité, M.C.; Späth, G.F.; Bussotti, G.; Porrozzi, R.; Morgado, F.N.; Llewellyn, M.; Schwabl, P.; Cupolillo, E. Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas. Genes 2020, 11, 4. https://doi.org/10.3390/genes11010004

AMA Style

Boité MC, Späth GF, Bussotti G, Porrozzi R, Morgado FN, Llewellyn M, Schwabl P, Cupolillo E. Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas. Genes. 2020; 11(1):4. https://doi.org/10.3390/genes11010004

Chicago/Turabian Style

Boité, Mariana C., Gerald F. Späth, Giovanni Bussotti, Renato Porrozzi, Fernanda N. Morgado, Martin Llewellyn, Philipp Schwabl, and Elisa Cupolillo. 2020. "Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas" Genes 11, no. 1: 4. https://doi.org/10.3390/genes11010004

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