Autoimmune Diseases Genetics
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 32
Special Issue Editor
Interests: autoimmune disorders; cancers; epigenetics, multiple sclerosis; type 1 diabetes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune diseases are complex disorders that require robust disease-modifying therapies. About 10% of the general population have one or more of the ~80 clinically distinct autoimmune diseases. Some autoimmune diseases cluster in a single patient, while members of the same family can harbor diverse autoimmune conditions. Intriguingly, more middle-aged women succumb to these diseases, which are also the leading cause of their deaths. Autoimmune diseases such as thyroiditis and type 1 diabetes are directed against specific targets, whereas diseases like lupus impact multiple organ systems. Genome-wide association studies have implicated numerous genes in a predisposition to autoimmune diabetes, but the disease-specific genes that could serve as disease biomarkers remain to be discerned. Accumulating evidence in preclinical models indicates a prominent role for the post-translational modifications of histone tails by acetylation in type 1 diabetes and multiple sclerosis. These and other epigenetic mechanisms, including DNA methylation and microRNA-mediated gene regulation, may impact the outcome of autoimmune disease. Clinical evidence for the involvement of epigenetic mechanisms in many autoimmune disorders remains to be garnered. This Special Issue will highlight recent advancements in the genetics and epigenetics of autoimmune disorders and the potential to detect these diseases early and treat them pre-emptively.
Dr. Sundararajan Jayaraman
Guest Editor
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Keywords
- autoimmune diseases
- biomarkers
- DNA
- epigenetics
- genes
- genetics
- microRNAs
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