Special Issue "Virus Evolution and Mutagenesis"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Population and Evolutionary Genetics and Genomics".

Deadline for manuscript submissions: 31 March 2020.

Special Issue Editors

Prof. Louis M. Mansky
E-Mail Website
Guest Editor
Institute for Molecular Virology, University of Minnesota, 18-242 Moos Tower, 515 Delaware St. SE, Minneapolis, MN 55455, USA
Interests: antiretroviral; nucleoside; mutation; drug synergy; therapeutic indices
Special Issues and Collections in MDPI journals
Prof. Esteban Domingo Solans
E-Mail Website
Guest Editor
CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM), Madrid, Spain
Interests: RNA virus quasispecies; quasispecies dynamics; lethal mutagenesis

Special Issue Information

Dear Colleagues,

Experimental evolution has immensely benefited from the study of viral evolution. Viruses have relatively rapid replication rates, which allows for the quantitative study of mutational processes and their impact on evolutionary rates, natural selection and population diversity. In particular, RNA viruses are known to exhibit high mutation rates and generate virus quasispecies, which harbor populations of closely-related genomes (i.e., mutant swarms or clouds) that lends to direct experimentation of fitness selection, adaptation, and virus evolution in connection with viral pathogenesis. The parallels between viral quasispecies and that of tumor cell heterogeneity and dynamics have also led to deeper insights into both areas of investigation.

This Special Issue on "Virus Evolution and Mutagenesis" seeks author contributions on topics that include replication fidelity, virus mutagenesis, mutation rates, population complexity, insights from deep sequencing, error thresholds, lethal mutagenesis, mutation-selection balance, recombination, fitness landscapes, mutational robustness, virus complementation/interference, and tumor cell heterogeneity and dynamics.

Prof. Esteban Domingo Solans
Prof. Louis M. Mansky
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mutation rate
  • quasispecies
  • population dynamics
  • deep sequencing
  • lethal mutagenesis
  • tumor cell heterogeneity

Published Papers

This special issue is now open for submission.
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