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Location, Location, Location: The Role of Nuclear Positioning in the Repair of Collapsed Forks and Protection of Genome Stability

1
Department of Biology, Tufts University, Medford, MA 02155, USA
2
Program in Genetics, Tufts University, Boston, MA 02111, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(6), 635; https://doi.org/10.3390/genes11060635
Received: 20 May 2020 / Revised: 29 May 2020 / Accepted: 4 June 2020 / Published: 9 June 2020
(This article belongs to the Special Issue Protective Mechanisms Against DNA Replication Stress)
Components of the nuclear pore complex (NPC) have been shown to play a crucial role in protecting against replication stress, and recovery from some types of stalled or collapsed replication forks requires movement of the DNA to the NPC in order to maintain genome stability. The role that nuclear positioning has on DNA repair has been investigated in several systems that inhibit normal replication. These include structure forming sequences (expanded CAG repeats), protein mediated stalls (replication fork barriers (RFBs)), stalls within the telomere sequence, and the use of drugs known to stall or collapse replication forks (HU + MMS or aphidicolin). Recently, the mechanism of relocation for collapsed replication forks to the NPC has been elucidated. Here, we will review the types of replication stress that relocate to the NPC, the current models for the mechanism of relocation, and the currently known protective effects of this movement. View Full-Text
Keywords: replication fork; fork collapse; replication fork barriers; fork restart; nuclear pore complex; sumoylation replication fork; fork collapse; replication fork barriers; fork restart; nuclear pore complex; sumoylation
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Whalen, J.M.; Freudenreich, C.H. Location, Location, Location: The Role of Nuclear Positioning in the Repair of Collapsed Forks and Protection of Genome Stability. Genes 2020, 11, 635.

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