Genetics of Myeloma Diseases
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 409
Special Issue Editors
Interests: bioinformatics; cancer; epidemiology; genetics; multiple myeloma; statistics
Special Issue Information
Dear Colleagues,
Genome-wide association studies (GWAS) provide an agnostic approach to investigating the genetic basis of complex diseases. In oncology, GWAS of nearly all common malignancies have been performed, and over 450 genetic variants associated with increased risks have been identified. Even though these studies have shown that common genetic variation contributes substantially to the heritable risk of many common cancers, and clinical application of GWAS is starting to provide opportunities for drug discovery and repositioning as well as for cancer prevention, most variants identified so far confer relatively small increments in risk and explain only a small proportion of familial clustering, leading many to question how the remaining, ‘missing’ heritability can be explained. The aim of this Special Edition is to provide potential research strategies, including and extending beyond current genome-wide association approaches, to illuminate additional genetic risk factors in the familial aggregation of multiple myeloma that can facilitate genetic counseling and personalized therapy in families as well as screening of other individuals at risk of developing cancer.
Dr. Hauke ThomsenDr. Subhayan Chattopadhyay
Guest Editors
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Keywords
- Multiple myeloma
- AL amyloidosis
- MGUS
- Plasma cell dyscrasia
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