Clinical Epigenetics in Gastroenterology
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (5 September 2024) | Viewed by 2072
Special Issue Editor
Interests: appendiceal cancer; epigenetics; translational research; cancer biomarkers; gastrointestinal cancer; precision oncology; epigenetic-specific biomarker
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Clinical epigenetics is a rapidly evolving field that holds great promise for revolutionizing the field of gastroenterology, offering novel insights into disease mechanisms to diagnose, prevent, and enable the development of targeted therapies for various gastrointestinal diseases. This issue explores the role of epigenetics in gastroenterology, highlighting key aspects such as disease mechanisms, diagnostic and prognostic markers, therapeutic strategies, and the role of liquid biopsy approaches in precision medicine.
Environmental factors, diets, and lifestyles are just a few elements that can induce changes in epigenetic mechanisms. Within gastroenterology, pivotal processes like DNA methylation, histone modification, and the regulation of non-coding RNAs (ncRNAs) are instrumental in both the onset and progression of gastrointestinal diseases. Several conditions, including pancreatic cancer, colorectal cancer, inflammatory bowel disease, and other rare diseases, have been associated with distinct epigenetic alterations. For instance, aberrant DNA methylation patterns are commonly observed in multiple gastrointestinal cancers, leading to the silencing of tumor suppressor genes and oncogene activation. Similarly, histone modifications and ncRNA have been implicated in the pathogenesis of inflammatory bowel disease, affecting inflammatory pathways and immune responses.
As research in this area continues to advance, it is expected to significantly impact the management of gastrointestinal diseases, improving patient care and clinical outcomes. Topics can cover but are not limited to the following areas of interest.
- The interplay of genetics, epigenetics, and the cellular microenvironment.
- Epigenetic mechanisms in gastrointestinal diseases (epigenetic plasticity, chromatin remodeling, disease heterogeneity, and spatial biology).
- The epigenetic regulation of immune responses.
- The integration of clinical epigenetics and systems biology approaches.
- Epigenetic engineering and its potential application in gastrointestinal diseases.
- Liquid and tissue biopsy in precision medicine (diagnostic, prognostic, therapeutic targets, surveillance, tissue of origins, and minimal residual diseases).
Dr. Anup R. Sharma
Guest Editor
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Keywords
- epigenetics
- gastrointestinal diseases
- DNA methylation
- histone modification
- RNAs
- diagnostic
- biomarkers
- precision medicine
- pancreatic cancer
- colorectal cancer
- inflammatory bowel disease
- and other rare diseases
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