Cancer Epigenetics-Recent Developments in Epigenetic Diagnostics and Therapy
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (15 August 2021) | Viewed by 15778
Special Issue Editor
Interests: head and neck cancer; epigenetics; CNS cancer; colorectal cancer; targeted therapy; Wnt signaling pathway; metabolism of cancer cells; metronomic therapy; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The field of cancer epigenetics has flourished in the past twenty years, and our knowledge and understanding of epigenetic abnormalities has expanded enormously. This has resulted in the introduction of therapeutics targeting epigenetic aberrations in patients with hematological cancers and solid tumors. Additionally, DNA methylation-based cancer biomarkers were successfully developed and introduced into clinical practice.
On the other hand, the complexity of epigenetic phenomena, which emerges from epigenomic studies, leads to new questions about the basic mechanisms of action of the epigenetic machinery and the mechanisms of its dysregulation in cancer. The picture of epigenetic modifications in various physiological and pathological conditions becomes much more detailed, drawing attention to the many interactions between epigenetic writers, readers and erasers, and the cross-talk between epigenetics and, e.g., metabolic pathways. The accumulating knowledge allows its translational implementation in oncological diagnostics and therapy.
I hope that this Special Issue on Cancer Epigenetics will be a creative space for presenting the results of novel studies and exchanging ideas about the significance of DNA methylation and histone modifications in cancer. What is needed is in-depth synthesis of current knowledge, but also marking the unknown terrain in the field, in order to be able to ask the right questions in the future. Therefore, you are invited to contribute to this discussion.
Dr. Jarosław Paluszczak
Guest Editor
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Keywords
- Cancer epigenetics
- DNA methylation
- Histone modifications
- Chromatin
- Epigenetic biomarkers
- Epigenetic readers, writers, and erasers as therapeutic targets
- Epigenetic therapy
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