Special Issue "From Genes to Therapy in Autism Spectrum Disorder"
Deadline for manuscript submissions: closed (20 June 2021) | Viewed by 27058
Interests: autism spectrum disorder; attention-deficit/hyperactivity disorder; conduct disorder; genetics; neurobiology; intervention
Interests: genetic architecture of neurodevelopmental disorders
Interests: autism; ADHD; intellectual disability; Phelan-McDermid syndrome; child psychiatry; neurogenetics; neurodevelopment; psychopharmacology
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Autism spectrum disorder (ASD) is a neurodevelopmental disorder with onset in early childhood. While highly heterogeneous, its core manifestations always include persistent difficulties in social interaction and communication, as well as a pattern of restricted interests and/or repetitive behaviors. In addition, psychiatric comorbidity is frequent and genetic risk overlaps with some other mental and neurodevelopmental disorders. This condition in most cases persists over the lifespan, with high social, educational, and health care costs.
Current psychopharmacological treatment can improve many comorbid symptoms, but not core autism symptom domains, which have a dramatic impact on the quality of life of patients and their families. A better understanding of the pathophysiological mechanisms underlying these symptoms is a crucial first step towards the development of such treatments. Over the past decade or so, it has become increasingly clear that ASD is highly heterogeneous, both at the phenotypic level (symptoms, co-morbidity, adaptive behavior, cognition, and trajectory) and at the level of etiology (genotype, environmental factors, neurobiological mechanisms). This heterogeneity poses a formidable challenge to those working to discover pharmacological treatments for the condition.
This challenge is at the heart of this Special Issue. Here, we aim to collect a set of contributions providing state-of-the-art coverage ranging from the theoretical framework linking genetics to human behavior and therapy, to initial practical examples of how genetics can provide valuable insights into the personalized clinical management of individuals with autism. In addition to the role of “autism genes”, special attention will be devoted to function-specific “gene networks”, to what they can tell us about the neurobiological processes underlying ASD, and how this information can in turn generate psychopharmacological predictions, testable using ethical and clinically reliable approaches.
Prof. Christine M. Freitag
Dr. Jacob A. S. Vorstman
Prof. Antonio Persico
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- autism spectrum disorder
- copy number variation
- single gene
- gene network
- gene ontology
- pharmacologic therapy