Gene Regulation in Cell Fate and Function
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 August 2026 | Viewed by 155
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cell fate decisions and cellular functions are fundamental processes governing multicellular life, from development through to tissue maintenance, repair, and regeneration. Their dysregulation is tightly linked to major diseases including cancer, aging, and neurodegeneration. Increasing our understanding of these regulatory mechanisms is significantly valuable for basic biology and translational medicine and offers promising opportunities for bioengineering and pharmaceutical innovation.
Gene regulation controls cell fate and function through intricate interactions among cellular cues, transcriptional networks, and epigenetic programs. Recent technological advances—including super-resolution imaging, omics technologies, protein structural determination, and interdisciplinary AI-based modeling—have enabled the decoding of gene regulation with unprecedented spatial and temporal resolution. These insights provide new toolkits for manipulating cellular outcomes.
This Special Issue welcomes original research and critical reviews addressing gene regulation in cell fate and function. The topics of this collection include genome architecture and organization (e.g., chromosomal arrangements and phase separation-mediated nuclear compartmentalization), transcriptional networks, epigenetic regulation, cancer progression, stem cell differentiation and regeneration, wound healing and tissue repair, and cellular cues signaling to transcription factors—including stress, mechanical forces, and metabolism. By highlighting advances in gene regulation, this Special Issue seeks to deepen understanding of the regulatory mechanisms underlying cell fate decisions and cellular functions.
Dr. Yi Liu
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gene regulation
- cell fate
- cell function
- transcriptional network
- genome architecture and organization
- epigenetic regulation
- differentiation
- regeneration
- wound healing
- stem cell
- cancer
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