Molecular Mechanisms of Embryogenesis in Mammal
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".
Deadline for manuscript submissions: 25 August 2025 | Viewed by 66
Special Issue Editor
Special Issue Information
Dear Colleagues,
Development, a fascinating process that is exclusive to multicellular organisms, transforms a single cell—the fertilized oocyte—into a three-dimensional organism capable of reproduction. This exquisitely regulated process involves multiple genes that interact through the proteins and RNAs whose synthesis they control, orchestrating a precise sequence of molecular and cellular events.
In its early stage, development progresses through the formation of the embryo (embryogenesis), a period that spans from the fusion of the two gametes to the formation of primordia, which are embryonic structures that create adult organs. This process involves a series of complex and coordinated biological events, including cell proliferation, differentiation, migration, apoptosis, and organogenesis, all of which are tightly regulated to ensure proper development. Errors in these processes can lead to developmental disorders, structural abnormalities, or even embryonic lethality.
This Special Issue of Genes will cover each and every process involved in mammalian embryogenesis: fertilization, blastula formation, gastrulation, and the organogenesis of different organs until the fetus emerges. Additionally, this Special Issue will also address the genetic and epigenetic mechanisms governing these processes, as well as their evolutionary significance. Understanding embryonic development is crucial not only for basic research but also for studying the origins of hereditary malformations, congenital diseases, and potential therapeutic interventions.
Dr. Federico Zurita
Guest Editor
Manuscript Submission Information
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Keywords
- gene regulation
- blastocyst
- chromatin
- cell migration
- gastrulation
- mouse
- MicroRNAs
- apoptosis
- neurulation
- organogenesis
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