Novel Therapies for the Treatment of Inflammatory Bowel Disease

A special issue of Gastrointestinal Disorders (ISSN 2624-5647).

Deadline for manuscript submissions: 25 December 2025 | Viewed by 655

Special Issue Editors


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Guest Editor
Department of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand
Interests: paediatric; inflammatory bowel disease; functional gastrointestinal disorders; coeliac disease; outcome meausures; non-clinical outcomes
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Guest Editor
Department of Paediatrics, Christchurch Hospital, University of Otago, Christchurch 4710, New Zealand
Interests: inflammatory bowel disease; coeliac disease; improving Crohn’s outcomes; intestinal inflammatory biomarkers; nutritional aspects of gut diseases; host–pathogen interactions in the gut (and how these relate to chronic gut diseases)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that inflammatory bowel disease can be a heterogenous condition with great diversity in presentation, disease course, and response to treatment. For patients that have a poor treatment response or experience adverse events relating to certain drug regimens, novel efficacious therapies may be utilised to provide symptom relief and reduce disease activity. Novel therapies include emerging treatments that are still in the experimental stage, newly approved therapies, treatments that have been effective in other inflammatory conditions and have a role in IBD, and isolated therapies that have been successfully implemented for certain individuals.

We invite papers that report quantified outcomes on the implementation of novel therapies and welcome original studies, systematic reviews and meta-analyses, case-reports, and scoping reviews.

Dr. Angharad Vernon-Roberts
Prof. Dr. Andrew Day
Guest Editors

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Keywords

  • inflammatory bowel disease
  • treatment/therapies
  • disease activity
  • remission
  • symptom resolution
  • drugs
  • nutrition.

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Published Papers (1 paper)

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Review

17 pages, 1627 KB  
Review
Inflammatory Bowel Disease and Pharmacotherapeutic Treatment for Healthcare Providers: A Pedagogic Tutorial
by Charlotte Silvestre, Julien Antih, Baptiste Perrier, Lucas Fabrega, Florence Bichon and Patrick Poucheret
Gastrointest. Disord. 2025, 7(3), 58; https://doi.org/10.3390/gidisord7030058 - 16 Sep 2025
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Abstract
Background: Inflammatory bowel disease (IBD) represents significant health challenges on a global scale, primarily encompassing Crohn’s disease and ulcerative colitis. These conditions are characterized by cycles of relapse and remission. Current treatment options, including conventional chemical therapies and biologics such as anti-Tumor Necrosis [...] Read more.
Background: Inflammatory bowel disease (IBD) represents significant health challenges on a global scale, primarily encompassing Crohn’s disease and ulcerative colitis. These conditions are characterized by cycles of relapse and remission. Current treatment options, including conventional chemical therapies and biologics such as anti-Tumor Necrosis Factor α (anti-TNFα), anti-integrin, anti-interleukins 12 (IL-12) or 23 (IL-23) agents, Janus Kinase (JAK) inhibitors, and sphingosine-1-phosphate (S1p) receptor modulators, provide symptomatic relief but do not offer a cure. These therapies are associated with both localized and systemic adverse effects, necessitating careful patient monitoring. Probiotics and prebiotics have been investigated for their potential to enhance gut microbiota diversity, which may assist in managing IBD. However, their efficacy in preventing disease flares remains limited. Recent advances in drug delivery systems, including pressure-based and pH-sensitive formulations, aim at enhancing localized treatment efficacy while minimizing adverse effects. Additionally, a pharmacogenomic approach could improve treatment personalization, optimize therapeutic outcomes, and enhance patients’ quality of life by addressing mental health needs and ensuring comprehensive follow-up care. Despite increased awareness and education among healthcare providers regarding IBD, there is still a need for clearer guidance on available treatment options. Objective: This review aims at providing deeper understanding of IBD management strategies, ultimately striving to improve the quality of care for individuals affected by this disease. Full article
(This article belongs to the Special Issue Novel Therapies for the Treatment of Inflammatory Bowel Disease)
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