Epigenetic Regulation in Cancer

A special issue of Epigenomes (ISSN 2075-4655).

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 2629

Special Issue Editor


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Guest Editor
Epigenetics and Disease Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
Interests: molecular epigenetics; chromatin dynamics; regulation of gene expression; transcriptomics; hypoxic signalling; cancer metastasis
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Special Issue Information

Dear Colleagues,

Epigenetic modifications of histones, DNA and RNA molecules are key regulatory mechanisms that alter gene expression. The deregulation of this process has been recognized as a key factor contributing to tumor development and progression. Epigenetic regulators can silence the expression of tumor suppressors and activate oncogenes, thereby influencing both the initiation and the progression of the disease. In addition, their ability to alter the genetic landscape in response to external stimuli represents a key factor in cellular adaptation to changes in the microenvironment. A molecular understanding of the role that epigenetic regulators play will translate into approaches that advance therapeutic strategies for cancer patients.

The present Special Issue aims to publish high-quality research articles, as well as review contributions, on a variety of topics related to epigenetic regulators and therapeutic developments.

Potential topics include, but are not limited to:

  • Novel epigenetic targets in cancer.
  • Tumor microenvironment.
  • Epitranscriptomics.
  • Epigenetic editing.
  • Current state of epigenetic therapies in cancer.
  • Methods of new epigenetic therapy development.

Dr. Jason S. Lee
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer epigenetics
  • epitranscriptomics
  • epigenetic therapy

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Published Papers (1 paper)

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Review

13 pages, 755 KiB  
Review
Evaluation of Exosomal miRNA as Potential Biomarkers in Cervical Cancer
by Jéssika Aline do Nascimento Medeiros, Ayane Cristine Alves Sarmento, Emanuelly Bernardes-Oliveira, Ronnier de Oliveira, Maysa Eunice Grigorio Bezerra Lima, Ana Katherine Gonçalves, Deyse de Souza Dantas and Janaina Cristiana de Oliveira Crispim
Epigenomes 2023, 7(3), 16; https://doi.org/10.3390/epigenomes7030016 - 1 Aug 2023
Cited by 4 | Viewed by 2148
Abstract
Different studies show that small non-coding RNAs, such as microRNAs (miRNAs) obtained from exosomes, are considered potential biomarkers in several types of cancer, including cervical cancer (CC). Therefore, the present study seeks to present an overview of the role of circulating exosomal miRNAs [...] Read more.
Different studies show that small non-coding RNAs, such as microRNAs (miRNAs) obtained from exosomes, are considered potential biomarkers in several types of cancer, including cervical cancer (CC). Therefore, the present study seeks to present an overview of the role of circulating exosomal miRNAs with the potential to act as biomarkers for the diagnosis and prognosis of CC and to analyze the presence of these miRNAs according to the stage of CC. For this purpose, a review was developed, with articles consulted from the electronic databases MEDLINE/PubMed, Scopus, and Web of Science published between 2015 and 2021. Seven articles were included after a selection of studies according to the eligibility criteria. In addition to the methods used for sample analysis, detection, and isolation of miRNAs in each article, clinical data were also extracted from the patients studied, such as the stage of cancer. After analyzing the network of the seven miRNAs, they were associated with the immune system, CC progression and staging, and cisplatin resistance. With the belief that studies on miRNAs in cervical cancer would have major clinical implications, in this review, we have attempted to summarize the current situation and potential development prospects. Full article
(This article belongs to the Special Issue Epigenetic Regulation in Cancer)
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