Interventions Impacting the Natural History of Chronic Plaque Psoriasis
A special issue of Dermato (ISSN 2673-6179).
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 2498
Special Issue Editors
Interests: psoriasis; clinical dermatology; atopic eczema/dermatitis; venereology
Special Issues, Collections and Topics in MDPI journals
Interests: psoriasis; psoriatic arthritis; atopic dermatitis; metabolic syndrome; vitamin D; alopecia areata; autoimmune bullous diseases; hidradenitis suppurativa; biologic therapy; urticaria
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic plaque psoriasis is not only a cutaneous disease, but a systemic disorder. There is a growing body of epidemiological evidence supporting the associations between psoriasis and cardiometabolic, gastrointestinal, renal, malignancies and mood disorders. The pathogenesis of the intersection of psoriasis and comorbidities is not fully understood. Psoriatic skin produces a broad range of inflammatory cytokines that are released into the systemic circulation and fuel systemic inflammation. Other non-cutaneous sites, including adipose tissue, may contribute to this inflammatory state. Elevated systemic levels of cytokines support asymptomatic inflammation that can cause tissue damage over time. In addition, the natural clinical course of psoriasis has been poorly characterized. The risk of progression from mild to moderate–severe psoriasis is unclear. Identifying prognostic factors that negatively affect the clinical course of psoriasis may provide an important advantage, enabling early therapeutic intervention of patients at risk of worsening disease.
Drawing on experience with other immune-mediated diseases, such as rheumatoid arthritis and Crohn's disease, it has been hypothesized that timely systemic treatment targeting pathogenic cytokines may not only improve skin symptoms but also systemic inflammation. The objective of the Special issue is to collect evidence the impact of interventions on the natural history of plaque psoriasis.
Experimental and observational studies, systematic reviews and meta-analyses and narrative reviews are welcome.
Dr. Francesco Bellinato
Dr. Paolo Gisondi
Guest Editors
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Keywords
- psoriasis
- biologics
- disease course
- systemic inflammation
- comorbidities
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