Special Issue "Epigenetic Regulation in Periodontal Disease"
A special issue of Dentistry Journal (ISSN 2304-6767).
Deadline for manuscript submissions: closed (31 August 2020).
Interests: epigenetics; chronic inflammation; tissue regeneration
Special Issues, Collections and Topics in MDPI journals
The focus of this Special Issue entitled “Epigenetic Regulation in Periodontal Diseases” is to provide an overview of the latest research on the role of epigenetic mechanisms in periodontal diseases. It will cover both pre-clinical and clinical research.
The term epigenetics refers to changes in gene expression that are independent of mutations or changes in the genetic coding. Epigenetic mechanisms include chemical alterations of DNA and its associated proteins, called histones. Epigenetic changes lead to remodeling of the chromatin, resulting in activation or inactivation of genes.
Chronic inflammatory diseases, such as periodontitis, have specific target tissues in which the inflammation results in tissue breakdown. A specific gene may possess different epigenetic patterns depending on the cell type, resulting in local and systemic expression of the gene. This indicates a local, site-specific change in the immune response to external stimuli and/or the inflammatory response itself, which may differ among individuals and add to the susceptibility to disease.
The growing knowledge about epigenetics contributes to a better understanding regarding the interactions between genes and the environment and may explain why patients with the same clinical phenotype respond differently to treatment. In addition, knowledge regarding local and genetic factors in the immune response may be applicable in diagnostics and in identifying individuals at risk of developing disease. Since epigenetic mechanisms are reversible, it may be possible to use this knowledge to reverse these changes, thereby inhibiting or preventing disease progression.
Identifying epigenetic patterns associated with the development of periodontitis may also improve personalized approaches that can be used to individualize treatment plans for patients with periodontitis.
Assoc. Prof. Lena Larsson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- periodontal diseases
- histone acetylation
- histone methylation
- DNA methylation
- pre-clinical research
- clinical research