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Neurorehabilitation
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Neurorehabilitation

A special issue of Clinical and Translational Neuroscience (ISSN 2514-183X).

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 19438

Special Issue Editors

Prof. Dr. Rene M. Muri

E-Mail Website
Guest Editor
University Hospital Bern, Bern, Switzerland
Interests: neurorehabilitation; telerehabilitation; robotics; brain stimulation; virtual reality; serious games; evidence-based medicine; brain injury; spinal cord injury
Prof. Dr. Arseny A. Sokolov

E-Mail Website
Guest Editor
University Hospital of Lausanne, Lausanne, Switzerland
Interests: neurorehabilitation; telerehabilitation; serious video games; virtual reality; social cognition; brain stimulation; brain injury; neuroimaging; brain connectivity; cerebellum
Prof. Dr. Adrian G. Guggisberg

E-Mail Website
Guest Editor
Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
Interests: neurorehabilitation
Prof. Dr. Armin Schnider

E-Mail Website
Guest Editor
Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences, Geneva University Neurocenter, Geneva, Switzerland
Interests: neurorehabilitation; telerehabilitation; robotics; brain stimulation; virtual reality; serious games; evidence-based medicine; brain injury; spinal cord injury

Special Issue Information

Dear Colleagues,

According to the WHO, the need for rehabilitation worldwide will increase due to changes in the health and characteristics of the population. For example, today people with neurological diseases are living longer, but may have more chronic diseases and disabilities. In the last few years, the development of new concepts for the neurorehabilitation of brain and spinal cord diseases has considerably broadened  the role of neurorehabilitative interventions, from acute treatment in the hospital and in-hospital rehabilitation to out-hospital rehabilitation and therapy at home.  However, health care resources are already overstretched, and for the future we need an improved, cost-effective patient management system. Furthermore, new approaches such as technology-assisted assessments and interventions, telerehabilitation or other therapeutic options at the patient’s home will optimize patient outcomes and quality of life.

For this Special Issue, we welcome research on a wide range of topics, including clinical and translational studies; studies using invasive and non-invasive brain stimulation; and technology-based interventions using robotics, wearable devices, virtual reality, or serious games.

We also welcome single case studies, systematic reviews, and meta-analyses on the topic of neurorehabilitation.

Prof. Dr. Rene M. Muri
Prof. Dr. Arseny A. Sokolov
Prof. Dr. Adrian G. Guggisberg
Prof. Dr. Armin Schnider
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinical and Translational Neuroscience is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurorehabilitation
  • telerehabilitation
  • robotics
  • brain stimulation
  • virtual reality
  • serious games
  • evidence-based medicine
  • brain injury
  • spinal cord injury

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Published Papers (5 papers)

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Research

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9 pages, 590 KiB  
Communication
The Role of Neurorehabilitation in Post-COVID-19 Syndrome
by Lara Diem, Oliver Höfle, Livia Fregolente and Robert Hoepner
Clin. Transl. Neurosci. 2023, 7(2), 13; https://doi.org/10.3390/ctn7020013 - 10 May 2023
Viewed by 2904
Abstract
Post-COVID-19 syndrome is an ongoing challenge for healthcare systems as well as for society. The clinical picture of post-COVID-19 syndrome is heterogeneous, including fatigue, sleep disturbances, pain, hair loss, and gastrointestinal symptoms such as chronic diarrhea. Neurological complaints such as fatigue, cognitive impairment, [...] Read more.
Post-COVID-19 syndrome is an ongoing challenge for healthcare systems as well as for society. The clinical picture of post-COVID-19 syndrome is heterogeneous, including fatigue, sleep disturbances, pain, hair loss, and gastrointestinal symptoms such as chronic diarrhea. Neurological complaints such as fatigue, cognitive impairment, and sleep disturbances are common. Due to the short timeframe of experience and small amount of evidence in this field, the treatment of post-COVID-19 syndrome remains a challenge. Currently, therapeutic options for post-COVID-19 syndrome are limited to non-pharmaceutical interventions and the symptomatic therapy of respective symptoms. In this article, we summarize the current knowledge about therapeutic options for the treatment of neurological symptoms of post-COVID-19 syndrome. Full article
(This article belongs to the Special Issue Neurorehabilitation)
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Review

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21 pages, 1011 KiB  
Review
Diagnostic and Therapeutic Approaches in Neurorehabilitation after Traumatic Brain Injury and Disorders of Consciousness
by Julian Lippert and Adrian G. Guggisberg
Clin. Transl. Neurosci. 2023, 7(3), 21; https://doi.org/10.3390/ctn7030021 - 9 Aug 2023
Cited by 2 | Viewed by 3335
Abstract
Severe traumatic brain injury (TBI) may cause disorders of consciousness (DoC) in the form of coma, unresponsive wakefulness syndrome (UWS), or minimally conscious state (MCS). Despite significant advancements made over the last two decades in detecting, predicting, and promoting the recovery of consciousness [...] Read more.
Severe traumatic brain injury (TBI) may cause disorders of consciousness (DoC) in the form of coma, unresponsive wakefulness syndrome (UWS), or minimally conscious state (MCS). Despite significant advancements made over the last two decades in detecting, predicting, and promoting the recovery of consciousness in TBI patients with DoC, the available diagnostic and treatment choices remain limited. In cases of severe TBI, the dissolution of consciousness both in the acute and post-acute phases constitutes one of the major clinical findings and challenges. In clinical settings, neurologists and neurorehabilitation specialists are called on to discern the level of consciousness in patients who are unable to communicate, and to project outcomes and recommend approaches to treatment. Standards of care are not available to guide clinical decision-making for this population, often leading to inconsistent, inaccurate, and inappropriate care. Recent studies refer to network-based mechanisms of consciousness as a more promising method to predict outcomes and functional recovery. A further goal is the modulation of neural networks underlying awareness and arousal as the main components of consciousness. This review centers on the difficulties in characterizing individuals experiencing post-traumatic DoC and on the recent advancements made in the identification and prognostication of consciousness recovery through the utilization of advanced neuroimaging and electrophysiological techniques as well as biomarkers. Moreover, we discuss new treatment approaches and summarize recent therapeutic recommendations. Full article
(This article belongs to the Special Issue Neurorehabilitation)
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7 pages, 247 KiB  
Review
Influence of Age on the Success of Neurorehabilitation
by Nicolas Broc and Armin Schnider
Clin. Transl. Neurosci. 2023, 7(1), 9; https://doi.org/10.3390/ctn7010009 - 1 Mar 2023
Cited by 1 | Viewed by 2003
Abstract
There is a general understanding that older adults suffering from a stroke have poorer outcomes and might benefit less from neurorehabilitation. This narrative review analyzes the conflicting evidence for the effect of aging on the success of neurorehabilitation after a stroke. While there [...] Read more.
There is a general understanding that older adults suffering from a stroke have poorer outcomes and might benefit less from neurorehabilitation. This narrative review analyzes the conflicting evidence for the effect of aging on the success of neurorehabilitation after a stroke. While there is convincing evidence that functional outcomes are negatively impacted by age, functional gains made during rehabilitation are less clearly impacted, and the effect of age seems to be related to other factors such as prestroke independence and therapy intensity, as well as the population studied. There is no evidence that would justify withholding high-intensity neurorehabilitation on the sole basis of age. Full article
(This article belongs to the Special Issue Neurorehabilitation)
8 pages, 238 KiB  
Review
Rehabilitation of Memory Disorders
by Armin Schnider and Radek Ptak
Clin. Transl. Neurosci. 2023, 7(1), 7; https://doi.org/10.3390/ctn7010007 - 14 Feb 2023
Viewed by 5303
Abstract
Memory disorders are common in clinical practice. This review focuses on the rehabilitation of anterograde amnesia, the inability to learn and retrieve new information, in non-degenerative brain disease. Diverse mnemonic strategies may be helpful in learning specific pieces of information. Their success also [...] Read more.
Memory disorders are common in clinical practice. This review focuses on the rehabilitation of anterograde amnesia, the inability to learn and retrieve new information, in non-degenerative brain disease. Diverse mnemonic strategies may be helpful in learning specific pieces of information. Their success also depends on the severity of associated cognitive failures, in particular, executive dysfunction. However, unless transfer to everyday activities is specifically trained, such strategies are of limited value in promoting independence in daily life. External memory aids are often necessary to allow for independent living. Learning to use them requires intact capacities such as procedural learning or conditioning. This review further discusses the rehabilitation of confabulation, that is, the emergence of memories of events that never happened. The rehabilitation of memory disorders needs to be tailored to patients’ individual capacities and needs. Full article
(This article belongs to the Special Issue Neurorehabilitation)
12 pages, 1622 KiB  
Review
Virtual Reality in the Rehabilitation of Cognitive Impairment after Stroke
by Alexia Bourgeois, Armin Schnider, Francesco Turri and Radek Ptak
Clin. Transl. Neurosci. 2023, 7(1), 3; https://doi.org/10.3390/ctn7010003 - 2 Jan 2023
Cited by 3 | Viewed by 4959
Abstract
Virtual reality (VR) is seen by some as a tool that may greatly improve, or even revolutionize cognitive rehabilitation. VR offers distinct advantages compared to classic rehabilitation using paper-and-pencil or computer-based training, such as immersion, the feeling of presence, embodiment of virtual players, [...] Read more.
Virtual reality (VR) is seen by some as a tool that may greatly improve, or even revolutionize cognitive rehabilitation. VR offers distinct advantages compared to classic rehabilitation using paper-and-pencil or computer-based training, such as immersion, the feeling of presence, embodiment of virtual players, ecological and multisensory stimulation. We here review recent clinical studies examining the effects of VR training in patients with stroke-induced cognitive deficits. Several trials reported evidence that VR training improves general cognition compared to standard cognitive training. However, the evidence remains controversial, as some of these studies had a high risk of bias. Regarding mood, there is some indication that immersive training improves depression scores in stroke patients, but the number of studies examining mood changes is very low. Finally, in the domain of spatial cognition the development of specific intervention techniques such as virtual prism adaptation provide avenues for clinical interventions, though well-controlled clinical trials are lacking. Together, the available evidence suggests that VR has the potential to improve rehabilitation particularly in domains requiring repetitive training in an immersed, ecological setting, or when a mismatch between body frames and the environment is created. Controlled clinical studies are required to examine the specific advantages of VR compared to classic interventions. Full article
(This article belongs to the Special Issue Neurorehabilitation)
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