Nanozyme-Based Sensing Platforms for Biomedical Applications

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "(Bio)chemical Sensing".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 373

Special Issue Editor


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Guest Editor
College of Life Science, Qingdao University, Qingdao 266071, China
Interests: nanozyme; molecular imprinting sensor; biosensor; bacterial detection; electrochemical sensing

Special Issue Information

Dear Colleagues,

Nanozymes, as artificial enzymes with tunable catalytic activities, have revolutionized biomedical sensing by overcoming the limitations of natural enzymes, including instability, high cost, and immunogenicity. This Special Issue highlights their transformative potential in diagnostics, disease monitoring, and point-of-care testing.

Nanozyme-based sensors enable ultrasensitive detection of biomarkers (e.g., glucose, pathogens) through colorimetric or electrochemical signals, with detection limits surpassing those of traditional methods. Beyond sensing, nanozymes integrate diagnosis and therapy by modulating reactive oxygen species (ROS). Antioxidant nanozymes mitigate oxidative stress in neurodegenerative diseases, while pro-oxidant variants selectively kill tumor cells. This dual functionality bridges the gap between diagnostic and therapeutic platforms.

Recent breakthroughs include biomimetic cascade catalysis, where nanozymes mimic multi-enzyme pathways for complex analyte detection. Their stability under harsh conditions (e.g., extreme pH and temperature) ensures reliability in resource-limited settings.

Dr. Tao Chen
Guest Editor

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Keywords

  • nanozyme
  • biosensor
  • bacterial detection
  • electrochemical sensing
  • biomedical applications

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Published Papers (1 paper)

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Review

29 pages, 4631 KB  
Review
Nanozyme-Powered Biosensing: A Systematic Review of Advanced Strategies for Bacterial Detection
by Bowen Wang, Yuhan Guo, Tao Chen and Maojin Tian
Chemosensors 2026, 14(5), 121; https://doi.org/10.3390/chemosensors14050121 - 21 May 2026
Abstract
Bacterial infections pose a persistent global threat to public health, driving the demand for rapid, sensitive, and specific detection technologies applicable to disease diagnosis, food safety, and environmental monitoring. Conventional methods like plate culture and polymerase chain reaction are often hampered by lengthy [...] Read more.
Bacterial infections pose a persistent global threat to public health, driving the demand for rapid, sensitive, and specific detection technologies applicable to disease diagnosis, food safety, and environmental monitoring. Conventional methods like plate culture and polymerase chain reaction are often hampered by lengthy procedures, dependence on complex instrumentation, and requirements for specialized personnel. The emergence of nanozymes and nanomaterials with enzyme-like catalytic activities has introduced a paradigm shift in biosensing, offering superior stability, cost-effectiveness, and tunable functionality compared to their natural counterparts. This review provides a comprehensive and systematic analysis of the latest advancements in nanozyme-mediated bacterial detection. It is structured around the primary signal transduction modalities: colorimetric, fluorescence, electrochemical, and surface-enhanced Raman scattering (SERS) analyses. For each approach, we outline the fundamental design principles, which commonly integrate a synergistic cascade of specific recognition, catalytic signal amplification, and signal readout, and present representative applications for detecting key pathogens like Staphylococcus aureus, Salmonella, and Listeria monocytogenes in complex samples. We evaluate and contrast the advantages, analytical performance, and appropriateness of these different platforms for various practical scenarios. Finally, we address current challenges, including achieving high specificity in complex matrices, precise modulation of nanozyme activity, and method standardization. Perspectives on future research directions aimed at developing next-generation, high-performance, and potentially portable bacterial detection systems are also provided. Full article
(This article belongs to the Special Issue Nanozyme-Based Sensing Platforms for Biomedical Applications)
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