Chemosensors and Their Application in Cell Imaging Studies

Dear Colleagues,

In 1867, the first fluorescent chemosensor was developed by F. Goppelsroder for the detection of Al³⁺ ion using morin chelate. Later, Prof. Anthony W. Czarnik and Prof. Amilra Prasanna de Silva contributed many seminal works and inspired others in the field of chemosensors. Organic fluorophore moieties have gained tremendous attention as a chemosensor for the detection of various analytes, such as metal ions, anions, and molecules due to their cost-effective synthesis and ability to bind with analytes showing a high association constant and low limit of detection. Various fluorescence mechanisms are involved in the detection of analytes such as chelation-enhanced fluorescence (CHEF), aggregation-induced emission (AIE), photo-induced electron transfer (PET), fluorescence resonance energy transfer (FRET), internal charge-transfer (ICT), and excited-state intramolecular proton-transfer (ESIPT). Furthermore, the concept of fluorescence sensing mechanisms has been extended to molecular logic gates, which interconnect information technology and chemistry. In addition, upon excitation with visible bandgap energy photons, various chemosensors exhibit high fluorescence intensity in the 7.0–9.0 pH range, which makes them suitable for biological applications.  

Though several breakthroughs have already been achieved in the field of chemosensing, there is still ample scope for developing new chemosensors which can simultaneously detect, remove, and cure the disease in living cells. We also need to develop chemosensors which can absorb multiple photons having energy in infrared regions and, consequently, make sure cells will not be damaged by low-energy photons during the study.

Authors are encouraged to submit their best experimental as well as theoretical findings that include new chemosensors along with their application in cell imaging studies. We also welcome high-quality reviews for analyte sensing and its practical use in cell imaging studies.

Dr. Atanu Jana
Guest Editor

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• Chemosensor
• Cell imaging
• Fluorescence
• Life time
• Molecular logic gate