Future Trends in Catalytic Organic Synthesis

A special issue of Chemistry (ISSN 2624-8549). This special issue belongs to the section "Molecular Organics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 629

Special Issue Editors


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Laboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci, 12/C, 87036 Arcavacata di Rende, Italy
Interests: new syntheses of high value added molecules through catalytic assembly of simple units; innovative syntheses of heterocyclic molecules of pharmaceutical; agrochemical; applicative interest; carbonylation chemistry; use of non-conventional solvents in organic synthesis; synthesis and semi-synthesis of bioactive compounds of pharmaceutical or agrochemical interest; synthesis of new materials for advanced applications; extraction; characterization; evaluation of the biological activity of bioactive principles from natural matrices
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Dipartimento di Chimica “Ugo Schiff”, Università degli Studi di Firenze, Via della Lastruccia, 13–50019 Sesto Fiorentino, FI, Italy
Interests: selenium; tellurium; catalysis; green chemistry; redox; functional group interconversions; synthetic methodologies; enzyme modulators
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Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Complesso Universitario di Monserrato, S.S. 554, Bivio per Sestu, I-09042 Monserrato, CA, Italy
Interests: development of new synthetic methods based on transformation of strained organic compounds; synthesis and exploitation of small ring compounds; design and preparation of highly functionalized heterocycle and aminoacid-inspired molecular scaffolds of biological and therapeutic interest; asymmetric synthesis
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Departamento de Quimica Organica, Facultad de Quimica, Regional Campus of International Excellence “Campus Mare Nostrum”, Universidad de Murcia, E-30100 Murcia, Spain
Interests: macrocycles; host-guest chemistry; synthetic organic chemistry; heterocyclic chemistry; molecular recognition; homogeneous catalysis; asymmetric synthesis; cross coupling; asymmetric catalysis

Special Issue Information

Dear Colleagues,

Catalysis is of fundamental importance for the development of sustainable and environmentally friendly organic synthesis. A catalyst can sequentially activate several simple building blocks in an ordered sequence to produce a high-value-added product in a one-pot, efficient procedure. Because catalysis is essential for achieving atoms and a step economy and lowering waste production, it is essential for the incorporation of the green chemistry principles in chemistry.

This Special Issue is aimed at highlighting novel catalytic processes of broad scope including but not limited to organo-, bio-, transition metal-, photoredox and electrochemical catalysis. Both experimental work aimed at increasing the efficiency and selectivity of important reactions and computational studies that predict catalytic behavior, optimize catalysts, and explore reaction pathways are appropriate.

Both original research articles and comprehensive review papers are welcome.

Prof. Dr. Bartolo Gabriele
Dr. Damiano Tanini
Dr. Angelo Frongia
Dr. Alberto Martinez-Cuezva
Guest Editors

Manuscript Submission Information

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Keywords

  • catalysis
  • heterocycles
  • organic synthesis
  • transition-metal catalysis
  • organocatalysis
  • asymmetric catalysis

Published Papers (1 paper)

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Research

20 pages, 7754 KiB  
Article
Reaction of β-Nitrostyrene with Diethyl Malonate in the Presence of Bispidines: The Unusual Role of the Organocatalyst
by Alexander I. Dalinger, Sabina F. Mamedova, Julia V. Burykina, Evgeniy O. Pentsak and Sergey Z. Vatsadze
Chemistry 2024, 6(3), 387-406; https://doi.org/10.3390/chemistry6030023 - 10 May 2024
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Abstract
The aim of this work was the investigation of novel organocatalysts for the Michael addition of diethyl malonate to β-nitrostyrene. The methodology of the study included NMR titration, reaction monitoring by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS), product characterization by [...] Read more.
The aim of this work was the investigation of novel organocatalysts for the Michael addition of diethyl malonate to β-nitrostyrene. The methodology of the study included NMR titration, reaction monitoring by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS), product characterization by MALDI, IR spectroscopy, scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and elemental analysis. As a result, evidence of supramolecular interactions between two pairs of components of the reaction was found. In addition to the supramolecular complexes, an unusual reaction, i.e., the Michael addition of NH-bispidines to β-nitrostyrene, was found, which led to previously unknown oligomers of β-nitrostyrene. A new mechanism for the catalytic action of NH-bispidine was proposed, which involved catalysis not by the initial organocatalyst but rather by its adduct with β-nitrostyrene. Thus, in this reaction, N-benzylbispidine acted as an initiator, and the real catalyst was the betaine formed during the initiation stage. Full article
(This article belongs to the Special Issue Future Trends in Catalytic Organic Synthesis)
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