Design, Engineering, and Application of Enzyme Cascade Systems
A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 152
Special Issue Editors
Interests: enzyme cascade reactions; interfacial biocatalysis; chemo-enzymatic cascades
Special Issue Information
Dear Colleagues,
Enzyme cascade systems, which orchestrate multiple biocatalytic steps sequentially, represent a rapidly advancing frontier in modern biocatalysis. By mimicking natural metabolic pathways, these systems offer unparalleled advantages for efficient, selective, and sustainable chemical synthesis, thereby bypassing the need for intermediate isolation and minimizing waste. This Special Issue aims to highlight cutting-edge research and reviews focused on the rational design, innovative engineering, and transformative applications of multi-enzyme cascades.
We welcome contributions that present novel strategies for cascade construction, including but not limited to, de novo pathway designs, enzyme engineering and compatibility optimization, innovative cofactor regeneration systems, and spatial organization techniques (e.g., co-immobilization, compartmentalization, and scaffold-assisted assembly). Submissions showcasing the application of enzyme cascades in challenging syntheses—such as the synthesis of pharmaceuticals, fine chemicals, chiral building blocks, and functional biomaterials—as well as those addressing their emerging applications in diagnostics, biosensing, and environmental remediation are also highly encouraged.
This Special Issue seeks to compile advances that bridge fundamental mechanistic understanding with practical implementation, pushing the boundaries of what can be achieved with engineered biocatalytic systems. We invite original research and comprehensive reviews that will inspire the next generation of integrated and efficient biocatalytic processes for a more sustainable future.
Prof. Dr. Zhiyong Sun
Dr. Ningning Zhang
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- enzyme cascade systems
- rational design
- enzyme engineering
- spatial organization
- cofactor regeneration
- pharmaceuticals
- fine chemicals
- sustainable synthesis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
