Genetics in Valvular Heart Diseases
A special issue of Cardiogenetics (ISSN 2035-8148). This special issue belongs to the section "Cardiovascular Genetics in Clinical Practice".
Deadline for manuscript submissions: 20 April 2027 | Viewed by 233
Special Issue Editor
2. Interdisciplinary Center for Health Sciences, Scuola Superiore Sant’Anna, 56127 Pisa, Italy
Interests: cardiac amyloidosis; heart failure; valvular heart diseases; acute aortic syndromes; telehealth; cardiology; hypertrophic cardiomyopathy; endocarditis
Special Issue Information
Dear Colleagues,
Valvular heart diseases (VHDs) represent a significant cause of cardiovascular morbidity and mortality worldwide, traditionally attributed to rheumatic, degenerative, or infectious processes. However, advances in cardiovascular genetics have revealed that genetic factors play a pivotal role in the development, progression, and clinical heterogeneity of many valvular disorders. Both inherited and sporadic forms of VHDs, including bicuspid aortic valve, arrhythmic mitral valve prolapse, and calcific aortic valve disease, have been linked to specific genetic variants and molecular pathways. Mutations affecting extracellular matrix remodeling, signaling pathways such as NOTCH, TGF-β, and WNT, as well as genes regulating valve morphogenesis and calcification, have provided new insights into disease mechanisms. Understanding the genetic basis of VHDs not only improves knowledge of pathophysiology but also opens avenues for early diagnosis, risk stratification, and personalized management. As genomic technologies continue to evolve, integrating genetics into clinical cardiology holds promise for improving prevention strategies and developing targeted therapies for valvular heart diseases.
This Special Issue invites contributions that explore this exciting frontier. We seek original research, comprehensive reviews, and insightful perspectives that connect genetic discoveries to molecular mechanisms, clinical diagnostics, and novel therapeutic strategies in the field of VHDs.
Dr. Giancarlo Trimarchi
Guest Editor
Manuscript Submission Information
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Keywords
- valvular heart disease
- genetics
- bicuspid aortic valve
- mitral valve prolapse
- NOTCH signaling
- calcific aortic valve disease
- molecular pathways
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