BioTech: 5th Anniversary

A special issue of BioTech (ISSN 2673-6284).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2197

Special Issue Editors


E-Mail Website
Guest Editor
Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
Interests: non-coding RNA; microRNA; miRNA
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor

E-Mail Website
Guest Editor
1. School of Biological Sciences, Institute for Global Food Security, Queen’s University Belfast, Belfast BT9 5DL, UK 2. Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Interests: computational biology; genomics and genetics; big data; pharmacogenomics; endocrine disruption; systems biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to celebrate the fifth anniversary of BioTech!

Over the years, our journal has experienced steady growth in the number of scientific articles it has published. Despite being relatively young, BioTech has achieved its first Impact Factor, reflecting its increasing importance—an accomplishment that was by no means guaranteed. This success is due to the invaluable contributions of our Editorial Board Members and reviewers, who have dedicated their time and expertise selflessly. We extend our heartfelt gratitude to them, as well as to the authors who have entrusted BioTech with their research.

We would also like take this opportunity to thank our Editorial Office. Their dedication and support have ensured that the journal maintains a rigorous yet efficient peer-review process, allowing for the timely publication of high-quality research.

In today’s rapidly evolving world, where life sciences and cutting-edge technologies are combined to address global challenges, our upcoming Special Issue marks a significant milestone. It offers a unique platform on which to integrate diverse aspects of biotechnology, celebrating innovation and progress in the field.

We invite contributions spanning a wide range of topics, including the following:

- Red biotechnology (medical applications);

- White biotechnology (industrial and environmental applications);

- Green biotechnology (agriculture and sustainability);

- Computational biology, which intersects with all these areas;

- The regulation of biotechnology, including policies and ethical considerations.

As a multidisciplinary platform, BioTech not only bridges the gaps between different biotechnology fields but also integrates computational biology and regulatory perspectives. Our goal is to provide a comprehensive approach to tackling global challenges while maintaining the journal’s reputation as an authoritative and innovative voice in biotechnology.

We welcome original research articles and comprehensive reviews from all biotechnology disciplines to this Special Issue. Topics of interest include, but are not limited to the following:

- Advances in gene therapies and diagnostic strategies;

- Coding and noncoding RNAs as bioactive molecules in precision medicine;

- Application of artificial intelligence in biological systems;

- Optimization of bioproduction processes;

- Development of bioremediation systems ;

- Innovations in sustainable agriculture and food production;

- Research addressing the economic, social, and environmental impacts of biotechnological solutions.

We look forward to your contributions and to engaging with a dynamic scientific community in the pursuit of groundbreaking advancements. We are open to candidates interested in managing specific topics or Special Issues. With the continued support of our editorial team, we remain committed to ensuring a fair, rapid, and rigorous review process and publishing high-impact papers that drive innovation in the biotechnology field.

Sincerely,

Prof. Dr. Massimo Negrini, Editor-in-Chief
Prof. Dr. Francesco Secundo, Section Editor-in-Chief
Prof. Dr. Gary Hardiman, Section Editor-in-Chief
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. BioTech is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 1621 KiB  
Article
Genomic Characterization of Linezolid-Resistant Clostridioides difficile Harboring cfr Variants
by Aikaterini Panou, Andigoni Malousi and Melina Kachrimanidou
BioTech 2025, 14(2), 42; https://doi.org/10.3390/biotech14020042 - 31 May 2025
Viewed by 661
Abstract
The emergence of antimicrobial resistance (AMR) in Clostridium difficile (C. difficile), particularly to last-line antibiotics such as linezolid, represents a critical challenge in clinical settings. This study investigates the genomic epidemiology of linezolid-resistant C. difficile, focusing on the distribution and [...] Read more.
The emergence of antimicrobial resistance (AMR) in Clostridium difficile (C. difficile), particularly to last-line antibiotics such as linezolid, represents a critical challenge in clinical settings. This study investigates the genomic epidemiology of linezolid-resistant C. difficile, focusing on the distribution and mutational patterns of the chloramphenicol–florfenicol resistance (cfr) gene and its association with multidrug resistance. We analyzed 514 clinical isolates (354 from NCBI Pathogen Detection, 160 from EnteroBase), revealing distinct prevalence patterns among cfr subtypes: cfr(C) was dominant (156/354 NCBI strains; 101/160 EnteroBase strains), whereas cfr(B) frequently harbored missense mutations (p.R247K, p.V294I, and less commonly p.A334T). The cfr(E) subtype was exclusively identified in ribotype 027 (RT027) strains. Notably, cfr(C) exhibited a strong association with RT017, correlating with a conserved 99 bp genomic deletion. Phylogenetic analysis linked cfr-carriage to predominant sequence types (ST1 in NCBI strains, ST37 in EnteroBase isolates). Furthermore, the co-occurrence of cfr with additional AMR genes conferred resistance to macrolides (erythromycin, azithromycin) and tetracyclines, indicating a convergent evolution toward multidrug resistance. These findings underscore the interplay between cfr mutations, hypervirulent ribotypes, and AMR dissemination, necessitating enhanced surveillance to mitigate the spread of resistant C. difficile lineages. Full article
(This article belongs to the Special Issue BioTech: 5th Anniversary)
Show Figures

Figure 1

Review

Jump to: Research

32 pages, 957 KiB  
Review
Broomrapes in Major Mediterranean Crops: From Management Strategies to Novel Approaches for Next-Generation Control
by Demosthenis Chachalis, Eleni Tani, Aliki Kapazoglou, Maria Gerakari, Angeliki Petraki, Francisco Pérez-Alfocea, Purificación A. Martínez-Melgarejo, Markus Albert, Khalil Khamassi and Mohamed Kharrat
BioTech 2025, 14(2), 40; https://doi.org/10.3390/biotech14020040 - 25 May 2025
Viewed by 1244
Abstract
Broomrapes (Orobanche and Phelipanche spp.) are parasitic weeds that significantly impact the productivity of major crops in the Mediterranean region, like tomato (Solanum spp.) and faba bean (Vicia faba) species. This review article extensively discusses management strategies to control [...] Read more.
Broomrapes (Orobanche and Phelipanche spp.) are parasitic weeds that significantly impact the productivity of major crops in the Mediterranean region, like tomato (Solanum spp.) and faba bean (Vicia faba) species. This review article extensively discusses management strategies to control broomrapes, which range from preventive measures to curative approaches. Additionally, it includes meaningful information on the intricate molecular mechanisms underlying the broomrape–host interaction, focusing on the host recognition of parasitic plant molecular patterns and the hormonal crosstalk that regulates the establishment of parasitism. Moreover, this article highlights the potential of breeding for resistance in cultivated crops, such as tomato and faba bean, as a sustainable, long-term solution to combat broomrape infestation. This review serves as a valuable resource for both researchers and farmers, offering insights for developing, implementing, and adapting effective and environmentally sustainable management practices for broomrape in Mediterranean agricultural systems. Full article
(This article belongs to the Special Issue BioTech: 5th Anniversary)
Show Figures

Figure 1

Back to TopTop