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Biomimetics
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Biomimetic Drug Delivery Systems 2024
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Biomimetic Drug Delivery Systems 2024

A special issue of Biomimetics (ISSN 2313-7673).

Deadline for manuscript submissions: closed (15 October 2024) | Viewed by 4998

Special Issue Editors

Prof. Dr. Vipul Bansal

E-Mail Website
Guest Editor
NanoBiotechnology Research Laboratory, Ian Potter NanoBioSensing Facility, School of Applied Sciences, RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia
Interests: biological and biomimetic synthesis of functional nanomaterials; ionic liquids mediated synthesis and self-assembly of functional nano(bio)materials; multifunctional nanomaterials; structure-function relationship of nanomaterials and composites; applications of nanomaterials in biosensing, bioimaging, drug-delivery, antimicrobials, wound-healing, (photo)catalysis and flexible electronics
Dr. Junge Chen

E-Mail Website
Guest Editor
School of Engineering Medicine, Beihang University, Beijing, China
Interests: exosome drug delivery; precision diagnosis and therapy of tumor; liquid metal micro-nano robot
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomimetic drug delivery systems are a new type of drug delivery system that has emerged rapidly in recent years. Extracts, isolates, and various natural particles such as mammalian cells, endogenous proteins, and pathogens from humans, animals, and microorganisms simulate their basic structural functions in the form of in vitro recombination. Biomimetic drug delivery systems have drawn extensive attention because of their excellent biocompatibility, lower immunogenicity, and ease of mimicking the biostructure and function of biological systems, making them promising drug delivery systems.

This Special Issue on bionic drug delivery systems calls for contributions from scientists and researchers working in all areas of biomimetic drug delivery systems and welcomes original research, theoretical, experimental, and review papers about biomimetic hydrogels, biomimetic micelles, biomimetic liposomes, biomimetic dendrimers, biomimetic polymeric carriers, biomimetic nanostructures, exosome drug delivery systems, and membrane-functional drug delivery systems, among others.

Prof. Dr. Vipul Bansal
Dr. Junge Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetics
  • drug delivery system
  • exosomes
  • hydrogels
  • micelles
  • liposomes
  • good targeting
  • low immunogenicity

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Published Papers (3 papers)

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Research

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19 pages, 4256 KiB  
Article
Sulfated and Phosphorylated Agarose as Biomaterials for a Biomimetic Paradigm for FGF-2 Release
by Aurelien Forget and V. Prasad Shastri
Biomimetics 2025, 10(1), 12; https://doi.org/10.3390/biomimetics10010012 - 30 Dec 2024
Cited by 1 | Viewed by 850
Abstract
Cardiovascular diseases such as myocardial infarction or limb ischemia are characterized by regression of blood vessels. Local delivery of growth factors (GFs) involved in angiogenesis such as fibroblast blast growth factor-2 (FGF-2) has been shown to trigger collateral neovasculature and might lead to [...] Read more.
Cardiovascular diseases such as myocardial infarction or limb ischemia are characterized by regression of blood vessels. Local delivery of growth factors (GFs) involved in angiogenesis such as fibroblast blast growth factor-2 (FGF-2) has been shown to trigger collateral neovasculature and might lead to a therapeutic strategy. In vivo, heparin, a sulfated polysaccharide present in abundance in the extracellular matrix (ECM), has been shown to function as a local reservoir for FGF-2 by binding FGF-2 and other morphogens and it plays a role in the evolution of GF gradients. To access injectable biomaterials that can mimic such natural electrostatic interactions between soluble signals and macromolecules and mechanically tunable environments, the backbone of agarose, a thermogelling marine–algae-derived polysaccharide, was modified with sulfate, phosphate, and carboxylic moieties and the interaction and release of FGF-2 from these functionalized hydrogels was assessed by ELISA in vitro and CAM assay in ovo. Our findings show that FGF-2 remains active after release, and FGF-2 release profiles can be influenced by sulfated and phosphorylated agarose, and in turn, promote varied blood vessel formation kinetics. These modified agaroses offer a simple approach to mimicking electrostatic interactions experienced by GFs in the extracellular environment and provide a platform to probe the role of these interactions in the modulation of growth factor activity and may find utility as an injectable gel for promoting angiogenesis and as bioinks in 3D bioprinting. Full article
(This article belongs to the Special Issue Biomimetic Drug Delivery Systems 2024)
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15 pages, 6112 KiB  
Article
Self-Exfoliated Guanidinium Covalent Organic Nanosheets as High-Capacity Curcumin Carrier
by Archita Sharma, Dhavan Sharma, Hengyu Lin, Hongcai (Joe) Zhou and Feng Zhao
Biomimetics 2024, 9(11), 709; https://doi.org/10.3390/biomimetics9110709 - 19 Nov 2024
Viewed by 1134
Abstract
Drug administration is commonly used to treat chronic wounds but faces challenges such as poor bioavailability, instability, and uncontrollable release. Existing drug delivery platforms are limited by chemical instability, poor functionality, complex synthesis, and toxic by-products. Presently, research efforts are focused on developing [...] Read more.
Drug administration is commonly used to treat chronic wounds but faces challenges such as poor bioavailability, instability, and uncontrollable release. Existing drug delivery platforms are limited by chemical instability, poor functionality, complex synthesis, and toxic by-products. Presently, research efforts are focused on developing novel drug carriers to enhance drug efficacy. Guanidinium Covalent Organic Nanosheets (gCONs) offer promising alternatives due to their high porosity, surface area, loading capacity, and ability to provide controlled, sustained, and target-specific drug delivery. Herein, we successfully synthesized self-exfoliated gCONs using a Schiff base condensation reaction and embedded curcumin (CUR), a polyphenolic pleiotropic drug with antioxidant and anti-inflammatory properties, via the wet impregnation method. The BET porosimeter exhibited the filling of gCON pores with CUR. Morphological investigations revealed the formation of sheet-like structures in gCON. Culturing human dermal fibroblasts (hDFs) on gCON demonstrated cytocompatibility even at a concentration as high as 1000 µg/mL. Drug release studies demonstrated a controlled and sustained release of CUR over an extended period of 5 days, facilitated by the high loading capacity of gCON. Furthermore, the inherent antioxidant and anti-inflammatory properties of CUR were preserved after loading into the gCON, underscoring the potential of CUR-loaded gCON formulation for effective therapeutic applications. Conclusively, this study provides fundamental information relevant to the performance of gCONs as a drug delivery system and the synergistic effect of CUR and CONs addressing issues like drug bioavailability and instability. Full article
(This article belongs to the Special Issue Biomimetic Drug Delivery Systems 2024)
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Review

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22 pages, 1359 KiB  
Review
Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier
by Hitaishi Sharma, Kannan Badri Narayanan, Shampa Ghosh, Krishna Kumar Singh, Prarthana Rehan, Aparajita Dasgupta Amist, Rakesh Bhaskar and Jitendra Kumar Sinha
Biomimetics 2025, 10(1), 25; https://doi.org/10.3390/biomimetics10010025 - 3 Jan 2025
Viewed by 2385
Abstract
Meningitis is the acute or chronic inflammation of the protective membranes, surrounding the brain and spinal cord, and this inflammatory process spreads throughout the subarachnoid space. The traditional drug delivery methods pose a disadvantage in limiting the capacity of crossing the blood–brain barrier [...] Read more.
Meningitis is the acute or chronic inflammation of the protective membranes, surrounding the brain and spinal cord, and this inflammatory process spreads throughout the subarachnoid space. The traditional drug delivery methods pose a disadvantage in limiting the capacity of crossing the blood–brain barrier (BBB) to reach the central nervous system (CNS). Hence, it is imperative to develop novel approaches that can overcome these constraints and offer efficient therapy for meningitis. Nanoparticle (NP)-based therapeutic approaches have the potential to address the limitations such as penetrating the BBB and achieving targeted drug release in specific cells and tissues. This review highlights recent advancements in nanotechnology-based approaches, such as functionalized polymeric nanoparticles, solid lipid nanoparticles (SLNs), nanostructured lipid carriers, nanoemulsions, liposomes, transferosomes, and metallic NPs for the treatment of meningitis. Recently, bionics has emerged as a next-generation technology in the development of novel ideas from biological principles, structures, and interactions for neurological and neuroinfectious diseases. Despite their potential, more studies are needed to ensure the safety and efficacy of NP-based drug delivery systems focusing on critical aspects such as toxicity, immunogenicity, and pharmacokinetics. Therefore, this review addresses current treatment strategies and innovative nanoparticle approaches, and it discusses future directions for efficient and targeted meningitis therapies. Full article
(This article belongs to the Special Issue Biomimetic Drug Delivery Systems 2024)
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