Advanced Research in Hematopoietic Stem Cells and Transplantation

Dear Colleagues,

The special field of acute leukemia is gathering much interest due to the expanded results of fascinating and novel new trials using many ‘first-in-class’ anti-leukemic agents with multiple modalities such as antibodies, cells, vaccines, and new immunomodulators. These developments have emerged from 50 years of research devoted to hematopoietic stem cells and even discoveries of cross-talk between veiled marrow microenvironment.

However, we have still a long way to go before we can overcome the hurdle of heterogeneities of molecular profiling in terms of measurable residual disease (MRD) for each patient with rapidly progressing leukemia to give more accurate guidance to therapeutic approaches at multiple time points or real-time in clinical settings.

On the other hand, outcomes for younger patients with AML are improving substantially due to the outstanding results of alternative donor transplantations, including unrelated, haploidentical, and cord blood sources. However, these are not a complete success yet, specifically for elderly patients, despite increasing numbers of transplants being performed for acute leukemia in older patients (greater than 60 or even 70 years old).

Therefore, we invite authors to submit original research and review articles that focus on recent trends of translational and/or clinical development based on the advanced research in hematopoietic stem cells and transplantation related issues. Potential topics include, but are not limited to the following:

• Hematopoietic stem cells and marrow microenvironment with new therapeutic strategies;
• Novel approaches of alternative donor transplantation for acute leukemia;
• Combined trials in hematopoietic stem cell transplantation (HSCT) and the role of MRD by novel concepts;
• Anti-leukemic immunotherapies with or without HSCT;
• Molecular biology of acute leukemia by using modern techniques of cellular analysis or related tools.

• Hematopoietic stem cells and marrow microenvironment with new therapeutic strategies;
• Novel approaches of alternative donor transplantation for acute leukemia;
• Combined trials in hematopoietic stem cell transplantation (HSCT) and the role of MRD by novel concepts;
• Anti-leukemic immunotherapies with or without HSCT;
• Molecular biology of acute leukemia by using modern techniques of cellular analysis or related tools.

Dr. Hee-Je Kim
Guest Editor

Manuscript Submission Information

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• acute leukemia
• AML
• marrow microenvironment
• hematopoietic stem cells
• alternative donor transplantation
• measurable residual disease
• immunotherapy
• molecular biology
• cellular analysis