Mechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases (3rd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 521

Special Issue Editor

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases are among the most prevalent health challenges of older age, profoundly affecting patient autonomy and imposing a significant burden on public health and healthcare systems.

Although certain molecular and cellular pathways are shared across multiple neurodegenerative conditions, others are disease-specific, and in many cases, the underlying mechanisms remain only partially understood. Even when the mechanisms are known, effective interventions to prevent, slow, or halt neurodegeneration remain limited.

This Special Issue invites original research articles and comprehensive reviews that explore the molecular and cellular mechanisms driving neurodegeneration and that advance potential therapeutic approaches. Manuscripts addressing related subjects are also welcome.

Dr. Fernando Cardona
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • cellular mechanisms
  • molecular mechanisms
  • mutations
  • neurodegeneration models
  • protein misfolding
  • protein aggregation
  • neuronal death
  • molecular therapy
  • cellular therapy
  • therapeutics
  • medical chemistry
  • drug screening

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issues

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 2004 KB  
Article
Isotopic H/D Exchange in Hydrogen Bonds Between the Nitrogenous Bases of the CAG Repeat Tract Makes It Possible to Stabilize Its Expansion in the ATXN2 Gene
by Anna Dorohova, Luis Velázquez-Pérez, Mikhail Drobotenko, Oksana Lyasota, Jose Luis Hernandez-Caceres, Roberto Rodriguez-Labrada, Alexandr Svidlov, Olga Leontyeva, Yury Nechipurenko and Stepan Dzhimak
Biomedicines 2025, 13(11), 2708; https://doi.org/10.3390/biomedicines13112708 - 4 Nov 2025
Viewed by 408
Abstract
Background: The isotopic composition of the body’s internal environment can affect its functional state. Such effects are realized, among other things, by inserting deuterium atoms into hydrogen bonds between pairs of nitrogenous bases of DNA molecules and modifying their mechanical properties. Methods [...] Read more.
Background: The isotopic composition of the body’s internal environment can affect its functional state. Such effects are realized, among other things, by inserting deuterium atoms into hydrogen bonds between pairs of nitrogenous bases of DNA molecules and modifying their mechanical properties. Methods: This study uses a coarse-grained mathematical model of DNA. Results: It has been established that in a certain range of the magnitude of the torque, with the presence of a deuterium atom within it, stabilization of the CAG repeat tract is observed. In addition, it was found that, regardless of which base pair the deuterium atom falls into in the CAG repeat tract, its stability increases and the probability of hairpin formation decreases, which may interfere with the reading of genetic information from the site encoding glutamine. Conclusions: Single H/D substitutions in the CAG repeat tract of the ATXN2 gene increase its stability by reducing the formation of open states, regardless of the position of deuterium. Full article
Show Figures

Figure 1

Back to TopTop