Advances and Application of Cryo-Electron Microscopy in Molecular Biology and Biomedicine

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 88

Special Issue Editors

1. Innovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China
2. Department of Molecular and Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Interests: cryo-EM; cryo-ET; molecular dynamic simulation; motor protein dynein

E-Mail Website
Guest Editor
Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
Interests: cryoEM; HIV; Epitope-mapping

Special Issue Information

Dear Colleagues,

Cryo-electron microscopy (cryo-EM) has emerged as a powerful tool for visualizing the structures of biological macromolecules and complexes with unprecedented detail. This Special Issue aims to present the forefront of cryo-EM research, focusing on advancements that have significantly improved data quality, resolution, and throughput. In particular, the integration of artificial intelligence (AI) techniques such as deep learning algorithms has revolutionized cryo-EM data analysis, enabling more accurate and efficient interpretation of complex structures. Contributions to this Special Issue will cover a wide range of topics, including, but not limited to, sample preparation methodologies, hardware innovations, image processing algorithms, and applications in molecular biology and biomedicine. By highlighting recent breakthroughs and discussing future directions, this Special Issue seeks to inspire further innovation and collaboration in the field of cryo-EM.

Dr. Yue Wang
Dr. Renbin Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cryo-electron microscopy
  • structural biology
  • molecular complexes
  • sample preparation
  • data acquisition
  • image processing
  • computational analysis
  • artificial intelligence
  • deep learning
  • molecular mechanisms
  • drug discovery
  • therapeutic development

Published Papers

This special issue is now open for submission.
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