Special Issue "Antioxidants and Antimicrobial Compounds from Natural Sources"

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (31 October 2018).

Special Issue Editor

Prof. Dr. Sabina Passamonti
E-Mail Website
Guest Editor
Department of Life Science, Università degli Studi di Trieste, Trieste, Italy
Interests: bilirubin detection; bilirubin metabolism, bilirubin membrane transport; anthocyanin bioavailability; polyphenol metabolites

Special Issue Information

Dear Colleagues,

Plants, animals and microorganisms synthetize metabolites with redox and/or antimicrobial activities. This Special Issue focuses on antioxidant compounds from natural sources that also have antimicrobial activities. The goal is to present success stories of identification, isolation, chemical and biological characterization of metabolites that offer the perspective to improve the management of food contamination, animal and human infection. This issue welcomes contributions that discuss about the rationale that lead to the discovery of antioxidant and antimicrobial compounds, the methods that enabled to characterize them as bioactive towards specific microbial agents and the advantage they offer over other antimicrobial drugs. Contributions describing the impact of natural compounds on the human or animal microbiome are accepted with interest. Systematic reviews of the literature, QSAR studies, multi- and interdisciplinary studies, technology reports, and accounts about individual or team endeavors on natural compound research are also most welcomed.

Dr. Sabina Passamonti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural compounds
  • redox activity
  • antiviral activity
  • anti-bacterial activity
  • anti-fungal activity
  • anti-parasite activity
  • chemical characterization
  • anti-microbial characterization
  • redox biology

Published Papers (1 paper)

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Open AccessArticle
Straw Wine Melanoidins as Potential Multifunctional Agents: Insight into Antioxidant, Antibacterial, and Angiotensin-I-Converting Enzyme Inhibition Effects
Biomedicines 2018, 6(3), 83; https://doi.org/10.3390/biomedicines6030083 - 02 Aug 2018
Cited by 4 | Viewed by 1917
Numerous studies provide robust evidence for a protective effect of red wine against many diseases. This bioactivity has been mainly associated with phenolic fractions of wines. However, the health effects of melanoidins in red sweet wines has been ignored. The goal of the [...] Read more.
Numerous studies provide robust evidence for a protective effect of red wine against many diseases. This bioactivity has been mainly associated with phenolic fractions of wines. However, the health effects of melanoidins in red sweet wines has been ignored. The goal of the present work was to unravel the antioxidant, antimicrobial, and angiotensin-I-converting enzyme (ACE) inhibitory properties of straw sweet wine melanoidins. Results demonstrated that melanoidins have a potential antioxidant activity, determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant power (FRAP) assays. The antimicrobial activity of melanoidins was also tested against Listeria monocytogenes, Salmonella Enteritidis, and Escherichia coli. Minimum inhibitory concentration (MIC) of isolated melanoidins against three bacterial strains ranged from 5 mg mL−1 to 10 mg mL−1. Finally, the ACE inhibitory effect of isolated melanoidins was evaluated, as it is linked with antihypertensive activity. Results showed that they have ACE-inhibitory activity ranging from 58.2 ± 5.4% to 75.3 ± 6.4% at a concentration level of 2 mg mL−1. Furthermore, the chemical properties of isolated melanoidins were determined. Results demonstrated that the skeleton of straw wine melanoidins is mainly composed of carbohydrates, and bear significant numbers of phenolic compounds that may play critical roles in their functional properties. Overall, this study describing the chemical composition and functional properties of melanoidin fractions isolated from a straw wine highlights that they can be exploited as functional agents for multiple purposes. Finally, melanoidins are an unexplored source of bioactive molecules in straw wines except from polyphenols that contribute to the health effects. Full article
(This article belongs to the Special Issue Antioxidants and Antimicrobial Compounds from Natural Sources)
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