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Biomedicines
Special Issues
Bioactive Natural Products for Novel Drugs
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Bioactive Natural Products for Novel Drugs

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 6548

Special Issue Editor

Dr. Kumar Katragunta

E-Mail Website
Guest Editor
National Center for Natural Product Research (NCNPR), School of Pharmacy, University of Mississippi, University, MS 38677, USA
Interests: exploration of natural products; analytical strategies; pharmacology and toxicology; food applications; traditional medicine

Special Issue Information

Dear Colleagues,

Secondary metabolites from medicinal plants or marine organisms are key sources for drug discovery processes and Phyto-based dietary supplements. The importance of natural product isolation, characterization, standardization, and exploring their biological properties through in vivo, in vitro, and in silico methods are necessary for human use. The aim of this issue is to study the chemistry of natural products with defined molecular compounds, followed by their bioactivities and toxicological studies. We intend to feature high-quality research, innovative approaches, and substantial knowledge from various research groups working on natural products, food applications, and natural products-based dietary supplements. This Special Issue covers recent research studies in relation to the discovery of Phyto-active secondary metabolites, natural product applications in nutraceuticals/dietary supplements in terms of analytical studies, formulation-based research, and pharmacological applications for human use from academia, research, and industry.

Dr. Kumar Katragunta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive secondary metabolites
  • dietary supplements
  • adulteration
  • mass spectrometry-based approaches
  • molecular networking
  • bioactivity and toxicological evaluations

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

64 pages, 2273 KiB  
Review
The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens
by Marília I. Figueira, Tiago M. A. Carvalho, Joana Macário-Monteiro, Henrique J. Cardoso, Sara Correia, Cátia V. Vaz, Ana P. Duarte and Sílvia Socorro
Biomedicines 2024, 12(8), 1636; https://doi.org/10.3390/biomedicines12081636 - 23 Jul 2024
Cited by 2 | Viewed by 2535
Abstract
The role of estrogens in prostate cancer (PCa) is shrouded in mystery, with its actions going from angelic to devilish. The findings by Huggins and Hodges establishing PCa as a hormone-sensitive cancer have provided the basis for using estrogens in therapy. However, despite [...] Read more.
The role of estrogens in prostate cancer (PCa) is shrouded in mystery, with its actions going from angelic to devilish. The findings by Huggins and Hodges establishing PCa as a hormone-sensitive cancer have provided the basis for using estrogens in therapy. However, despite the clinical efficacy in suppressing tumor growth and the panoply of experimental evidence describing its anticarcinogenic effects, estrogens were abolished from PCa treatment because of the adverse secondary effects. Notwithstanding, research work over the years has continued investigating the effects of estrogens, reporting their pros and cons in prostate carcinogenesis. In contrast with the beneficial therapeutic effects, many reports have implicated estrogens in the disruption of prostate cell fate and tissue homeostasis. On the other hand, epidemiological data demonstrating the lower incidence of PCa in Eastern countries associated with a higher consumption of phytoestrogens support the beneficial role of estrogens in counteracting cancer development. Many studies have investigated the effects of phytoestrogens and the underlying mechanisms of action, which may contribute to developing safe estrogen-based anti-PCa therapies. This review compiles the existing data on the anti- and protumorigenic actions of estrogens and summarizes the anticancer effects of several phytoestrogens, highlighting their promising features in PCa treatment. Full article
(This article belongs to the Special Issue Bioactive Natural Products for Novel Drugs)
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25 pages, 1683 KiB  
Review
Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways
by Arshad Husain Rahmani, Ahmad Almatroudi, Khaled S. Allemailem, Hajed Obaid A. Alharbi, Wanian M. Alwanian, Basmah Awwadh Alhunayhani, Mohammad Algahtani, Abdulrahman Theyab, Nahlah Makki Almansour, Ahmed N. Algefary, Solaiman Saleh Ali Aldeghaim and Amjad Ali Khan
Biomedicines 2023, 11(12), 3205; https://doi.org/10.3390/biomedicines11123205 - 1 Dec 2023
Cited by 11 | Viewed by 3223
Abstract
Cancer is a major public health concern worldwide in terms of mortality. The exact reason behind the development of cancer is not understood clearly, but it is evidenced that alcohol consumption, radiation, and exposure to chemicals are main players in this pathogenesis. The [...] Read more.
Cancer is a major public health concern worldwide in terms of mortality. The exact reason behind the development of cancer is not understood clearly, but it is evidenced that alcohol consumption, radiation, and exposure to chemicals are main players in this pathogenesis. The current mode of treatments such as surgery, chemotherapy, and radiotherapy are effective, but, still, cancer is a major problem leading to death and other side effects. However, safer and effective treatment modules are needed to overcome the adverse effects of current treatment modules. In this regard, natural compounds have been recognized to ameliorate diseases by exerting anti-inflammatory, anti-oxidative, and anti-tumor potential through several mechanisms. Mangiferin, a xanthone C-glucoside, is found in several plant species including Mangifera indica (mango), and its role in disease prevention has been confirmed through its antioxidant and anti-inflammatory properties. Furthermore, its anti-cancer-potential mechanism has been designated through modulation of cell signaling pathways such as inflammation, angiogenesis, PI3K/AKT, apoptosis, and cell cycle. This article extensively reviews the anticancer potential of mangiferin in different cancers through the modulation of cell signaling pathways. Moreover, the synergistic effects of this compound with some commonly used anti-cancer drugs against different cancer cells are discussed. More clinical trials should be performed to reconnoiter the anti-cancer potential of this compound in human cancer treatment. Further, understanding of mechanisms of action and the safety level of this compound can help to manage diseases, including cancer. Full article
(This article belongs to the Special Issue Bioactive Natural Products for Novel Drugs)
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