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Biomedicines
Special Issues
Retinal Diseases: Imaging and Treatment
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Retinal Diseases: Imaging and Treatment

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3347

Special Issue Editor

Dr. Cengiz Türksever

E-Mail Website
Guest Editor
Faculty of Medicine, University of Basel, 4001 Basel, Switzerland
Interests: retina; oct; oct-angiography; AMD; glaucoma; retinal oximetry; retinal vessel analysis

Special Issue Information

Dear Colleagues,

The studies on retinal diseases such as AMD, diabetic retinopathy, retinal vein occlusions and inherited retinal diseases have expanded seriously over the last years. Advances in the field of retinal imaging and treatment have opened new horizonts and are allowing us to have a better understanding of retinal diseases and treatment methods. Retinal imaging plays a key role not only in our daily routine but also in the field of retinal research. Today, retinal imaging is an unique supporting tool to understand retinal diseases and investigate new therapeutic methods and for the development of new treatment strategies.

The aim of this special issue is to clarify the pathogenesis of the main retinal diseases using retinal imaging, in order to identify new ocular and systemic biomarkers and new therapeutic strategies, as well. In this Special Issue, we welcome original articles about the study of retinal diseases. These include, but are not limited to, AMD, diabetic retinopathy, retinal vein occlusion, inherited retinal diseases, diagnosis, clinical features and preclinical research, and clinical trials of new treatments. Thank you for your contribution.

Dr. Cengiz Türksever
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retinal imaging
  • oct
  • oct-angiography
  • retina
  • biomarkers
  • AMD
  • diabetic retinopathy
  • anti-VEGF

Published Papers (2 papers)

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13 pages, 1894 KiB  
Article
Fluorescence Angiography with Dual Fluorescence for the Early Detection and Longitudinal Quantitation of Vascular Leakage in Retinopathy
by Benjamin Pomeroy, Alexander W. Venanzi, Wei Li, Abigail S. Hackam and Midhat H. Abdulreda
Biomedicines 2023, 11(2), 293; https://doi.org/10.3390/biomedicines11020293 - 20 Jan 2023
Cited by 1 | Viewed by 1356
Abstract
Background: Diabetic retinopathy (DR) afflicts more than 93 million people worldwide and is a leading cause of vision loss in working adults. While DR therapies are available, early DR development may go undetected without treatment due to the lack of sufficiently sensitive tools. [...] Read more.
Background: Diabetic retinopathy (DR) afflicts more than 93 million people worldwide and is a leading cause of vision loss in working adults. While DR therapies are available, early DR development may go undetected without treatment due to the lack of sufficiently sensitive tools. Therefore, early detection is critically important to enable efficient treatment before progression to vision-threatening complications. A major clinical manifestation of early DR is retinal vascular leakage that may progress from diffuse to more localized focal leakage, leading to increased retinal thickness and diabetic macular edema (DME). In preclinical research, a hallmark of DR in mouse models is diffuse retinal leakage without increased thickness or DME, which limits the utility of optical coherence tomography and fluorescein angiography (FA) for early detection. The Evans blue assay detects diffuse leakage but requires euthanasia, which precludes longitudinal studies in the same animals. Methods: We developed a new modality of ratiometric fluorescence angiography with dual fluorescence (FA-DF) to reliably detect and longitudinally quantify diffuse retinal vascular leakage in mouse models of induced and spontaneous DR. Results: These studies demonstrated the feasibility and sensitivity of FA-DF in detecting and quantifying retinal vascular leakage in the same mice over time during DR progression in association with chronic hyperglycemia and age. Conclusions: These proof-of-concept studies demonstrated the promise of FA-DF as a minimally invasive method to quantify DR leakage in preclinical mouse models longitudinally. Full article
(This article belongs to the Special Issue Retinal Diseases: Imaging and Treatment)
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24 pages, 4980 KiB  
Systematic Review
Intraoperative Optical Coherence Tomography in the Management of Macular Holes: State of the Art and Future Perspectives
by Filippo Confalonieri, Hanna Haave, Ragnheidur Bragadottir, Ingar Stene-Johansen, Xhevat Lumi, Lyubomyr Lytvynchuk and Goran Petrovski
Biomedicines 2022, 10(11), 2873; https://doi.org/10.3390/biomedicines10112873 - 9 Nov 2022
Cited by 2 | Viewed by 1627
Abstract
Background: Non-invasive diagnostic technologies in ophthalmology have substantially transformed contemporary clinical practice. Intraoperative optical coherence tomography (iOCT) systems have recently been used for various surgical interventions, including the treatment of full-thickness macular holes (FTMHs). Materials and Methods: We conducted a systematic review on [...] Read more.
Background: Non-invasive diagnostic technologies in ophthalmology have substantially transformed contemporary clinical practice. Intraoperative optical coherence tomography (iOCT) systems have recently been used for various surgical interventions, including the treatment of full-thickness macular holes (FTMHs). Materials and Methods: We conducted a systematic review on the use of iOCT and its possible benefits in the management of FTMHs, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). The level of evidence according to the Oxford Centre for Evidence-Based Medicine (OCEM) 2011 guidelines, and the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, were assessed for all included articles. Results: 1131 articles were initially extracted, out of which 694 articles were obtained after duplicates were removed and their abstracts screened. A total of 65 articles was included for full-text review. Finally, 17 articles remained that fulfilled the inclusion criteria. Conclusions: Even though there is just a small number of studies with solid results, the use of iOCT in FTMH surgery may be a helpful tool for both novice and experienced surgeons planning and managing difficult cases. Additionally, it could be used for teaching reasons and for exploring novel surgical techniques. Full article
(This article belongs to the Special Issue Retinal Diseases: Imaging and Treatment)
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