Placental, Vascular, and Immune Molecular Pathways in Pregnancy Complications
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 August 2026 | Viewed by 246
Special Issue Editors
Interests: high-risk pregnancy; obstetrics; gestational diabetes; maternal obesity; placental dysfunction; pregnancy-related hypertension; fetal growth restriction
Interests: perinatal medicine; early pediatric rehabilitation; postnatal complications of high risk pregnancies
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Special Issue Information
Dear Colleagues,
Pregnancy complications remain a major challenge in obstetric care and are a leading cause of maternal, fetal, and neonatal morbidity and mortality. Although advances in clinical surveillance and management have improved outcomes, many high-risk conditions are still diagnosed late in gestation when opportunities for targeted intervention are limited. A better understanding of the underlying pathophysiological processes is therefore essential to improve early detection, risk stratification, and prevention.
Increasing evidence indicates that common pregnancy complications, including preeclampsia, fetal growth restriction, preterm birth, and gestational metabolic disorders, share overlapping pathophysiological features related to placental dysfunction, vascular maladaptation, metabolic imbalance, and dysregulated maternal–fetal immune interactions. However, these mechanisms are often considered separately in clinical practice, limiting their integration into predictive models and individualized care.
This Special Issue aims to provide a clinically oriented overview of pathophysiological and translational insights into pregnancy complications, with emphasis on mechanisms that have clear relevance to diagnosis, prognosis, and therapeutic decision-making. Contributions that bridge clinical observations with experimental or translational data, such as biomarker studies, imaging–pathophysiology correlations, and clinically informed mechanistic research, are particularly encouraged. The goal of this Special Issue is to support clinicians by integrating emerging biological insights with practical implications for maternal–fetal care.
Dr. Milan Lackovic
Dr. Dejan Nikolić
Dr. Anita Barisic
Guest Editors
Manuscript Submission Information
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Keywords
- pregnancy-related complications
- pathophysiological mechanisms
- perinatal outcomes
- perinatal diagnosis
- placental dysfunction
- maternal–fetal interface
- fetal growth
- translational medicine
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