Neutrophil Extracellular Traps (NETs) in Immunity
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 332
Special Issue Editor
Interests: the main topic of my scientific interests focuses on the biology of neutrophils, with particular attention to the cellular mechanisms of innate immune response; I focus on the phenomenon of the formation of neutrophil extracellular traps (NETs) in various pathological conditions
Special Issue Information
Dear Colleagues,
The discovery of neutrophil extracellular traps (NETs) as a part of the central element of the innate immune response raised a number of questions regarding this phenomenon, prompting a reassessment of neutrophil functions. These questions concern the structure of NETs, as well as the inducers and inhibitors of their formation. The mechanism of NET formation and the signaling pathways involved in this process are still not fully understood. The question is whether all neutrophils are capable of NET formation; if not, what determines selected cells to carry out such a process? Do NETs cooperate with the migration and chemotaxis of neutrophils and other immunocompetent cells? If so, how? Is the formation and/or elimination of NETs a critical aspect of an innate immune response in a series of pathophysiological mechanisms?
Two decades of research into the formation of neutrophil extracellular traps have provided a wealth of data defining the pleiotropic range of NET activity. However, many questions remain unanswered, and opinions concerning the significance of NETs in the human body are not unanimous. A detailed understanding of mechanisms regulating NET formation might provide a basis of diagnostics and perhaps therapy for diseases in the pathogenesis of which neutrophils are involved.
Therefore, we encourage all authors exploring the subject of neutrophil extracellular traps to present their own research results in this Special Issue.
Dr. Marzena Garley
Guest Editor
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Keywords
- NETs
- neutrophils
- innate and adaptive immunity
