Reperfusion in Ischemic Stroke
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2664
Special Issue Editors
Interests: stroke; ischemic stroke; clinical neurology
Interests: dementia; Alzheimer’s diseases; Parkinson’s disease; polyneuropathies; stroke
Interests: stroke; ischemic stroke
Special Issue Information
Dear Colleagues,
This Special Issue aims to attract the interest of the entire stroke research community, highlighting both the challenges and the opportunities of recent advancements in knowledge around reperfusion pathophysiology in ischemic stroke.
Not all patients clinically improve after acute ischemic stroke early recanalization therapy: the restoration of blood flow (reperfusion) could lead to a paradoxical worsening of brain damage through a complex series of biochemical and cellular pathophysiological mechanisms, the so-called reperfusion injury. The disruption of the neurovascular unit, namely the cellular and extracellular components involved in the regulation of cerebral blood flow and blood–brain barrier (BBB) function (endothelial cells, basal lamina matrix, astrocyte, pericytes, neurons, and supporting cells), is responsible for the major clinical–radiological complications of acute ischemic stroke, cerebral edema, and hemorrhagic transformation. The current literature suggests that cerebral edema and hemorrhagic transformation share both pre-transcriptional and transcriptional factors and should be considered to belong to the same physio-pathological continuum, pointing out that blood components’ extravasation could represent the result of a complex process triggered by ischemic cascade.
Possible identification of druggable targets may pave the way to future neuroprotection strategies. Moreover, it might help to predict outcome before reperfusion treatments and therefore support decision making with a precision medicine approach.
Dr. Benedetta Piccardi
Dr. Marzia Baldereschi
Dr. Leonardo Renieri
Dr. Anna Letizia Allegra Mascaro
Guest Editors
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Keywords
Stroke reperfusion injuries
Neuroimaging in acute ischemic stroke
Neuroimaging of stroke reperfusion
Blood–brain barrier in ischemic stroke
Neurovascular unit in ischemic stroke
Stroke neuroprotection
Precision medicine in acute ischemic stroke
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