Correlative Light and Electron Microscopy (CLEM) in Biomedicine: Advances and Applications
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 62
Special Issue Editor
Interests: correlative light and electron microscopy; pathology; ultrastructural imaging; virus–host interactions; translational biomedical applications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Correlative light and electron microscopy (CLEM) has emerged as a powerful approach for bridging the gap between molecular localization and ultrastructural context. By integrating light and fluorescence microscopy with high-resolution electron microscopy, CLEM enables researchers to unravel complex biological processes in health and disease in unprecedented detail. This interdisciplinary technique has gained importance in diverse fields, including pathology, virology, oncology, neuroscience, and developmental biology.
We invite you to contribute to this Special Issue, which will showcase the latest advances, applications, and innovations in correlative light and electron microscopy (CLEM) that address fundamental and translational biomedical questions. We welcome contributions highlighting methodological developments, novel sample preparation techniques, instrumentation, image analysis workflows, and translational applications in clinical and preclinical research. The scope of this Special Issue is aligned with the journal’s mission to publish cutting-edge research in imaging and biomedicine.
This Special Issue provides a platform for original research articles and comprehensive reviews. We welcome contributions that present both technical innovations and biomedical applications. Research areas may include, but are not limited to, the following:
- Development of novel CLEM methodologies and workflows;
- Innovations in sample preparation, staining, and preservation for CLEM;
- Advances in instrumentation and multimodal imaging platforms;
- Integration of immunolabeling, cryo-techniques, and live-cell CLEM;
- Computational methods, image correlation software, and AI-based data analysis;
- Applications of CLEM in pathology, oncology, virology, and neuroscience;
- Translational and clinical applications of CLEM in biomedicine;
- Comparative studies with other multimodal imaging techniques.
I look forward to receiving your contributions.
Dr. Hideya Kawasaki
Guest Editor
Manuscript Submission Information
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Keywords
- CLEM
- correlative microscopy
- biomedicine
- pathology
- virology
- oncology
- immunolabeling
- cryo-microscopy
- ultrastructure
- image analysis
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