Early Diagnosis, Pathogenesis and Treatment Strategies of Atrial Fibrillation

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 4844

Special Issue Editors


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Guest Editor
Primary Health-Care Centre, Institut Catala de la Salut, Primary Care Service (SAP) Terres de l'Ebre, 43500 Tortosa, Spain
Interests: stroke; atrial fibrillation; public health; cardiovascular factors

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Guest Editor
Advanced Nursing Research Group, Medicine and Health Sciences, University Rovira i Virgili, 43002 Tarragona, Spain
Interests: stroke; risk factors; revascularization; secondary prevention; coping; psychological well-being

Special Issue Information

Dear Colleagues,

Atrial fibrillation (AF) is a common cardiac arrhythmia, the treatment strategies for which vary depending on the underlying causes and severity of the condition.

This Special Issue will provide an overview of the pathogenesis of AF, and the complex interplay between various mechanisms involved in its initiation, early diagnosis, and management. This issue will also review the different strategies for detecting individuals at high risk for AF; the management and treatment of AF diagnosed early using methods such as artificial intelligence and digital devices; pharmacological therapies such as antiarrhythmic drugs and rate control agents; non-pharmacological interventions such as catheter ablation and electrical cardioversion; and stroke prevention strategies such as anticoagulation therapy. Moreover, we will discuss the challenges and limitations of early diagnosis, as well as current treatment options, and highlight emerging strategies that may offer new approaches to managing AF. 

Dr. José-Luis Clúa-Espuny
Dr. Silvia Reverté-Villarroya
Guest Editors

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Keywords

  • atrial fibrillation
  • diagnosis
  • stroke
  • cardioversion
  • ablation
  • cardiovascular risk
  • secondary prevention
  • artificial intelligence
  • devices

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Published Papers (1 paper)

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Review

19 pages, 3863 KiB  
Review
Pollutants, including Organophosphorus and Organochloride Pesticides, May Increase the Risk of Cardiac Remodeling and Atrial Fibrillation: A Narrative Review
by Ewen Le Quilliec, Alexia Fundere, Doa’a G. F. Al-U’datt and Roddy Hiram
Biomedicines 2023, 11(9), 2427; https://doi.org/10.3390/biomedicines11092427 - 30 Aug 2023
Cited by 6 | Viewed by 4400
Abstract
Atrial fibrillation (AF) is the most common type of cardiac rhythm disorder. Recent clinical and experimental studies reveal that environmental pollutants, including organophosphorus–organochloride pesticides and air pollution, may contribute to the development of cardiac arrhythmias including AF. Here, we discussed the unifying cascade [...] Read more.
Atrial fibrillation (AF) is the most common type of cardiac rhythm disorder. Recent clinical and experimental studies reveal that environmental pollutants, including organophosphorus–organochloride pesticides and air pollution, may contribute to the development of cardiac arrhythmias including AF. Here, we discussed the unifying cascade of events that may explain the role of pollutant exposure in the development of AF. Following ingestion and inhalation of pollution-promoting toxic compounds, damage-associated molecular pattern (DAMP) stimuli activate the inflammatory response and oxidative stress that may negatively affect the respiratory, cognitive, digestive, and cardiac systems. Although the detailed mechanisms underlying the association between pollutant exposure and the incidence of AF are not completely elucidated, some clinical reports and fundamental research data support the idea that pollutant poisoning can provoke perturbed ion channel function, myocardial electrical abnormalities, decreased action potential duration, slowed conduction, contractile dysfunction, cardiac fibrosis, and arrhythmias including AF. Full article
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