Immunogenetic Regulations for Disease Prognosis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 1000

Special Issue Editors


E-Mail Website
Guest Editor
Translational Research & Sustainable Healthcare Management, Institute of Advanced Materials, IAAM, 590 53 Ulrika, Sweden
Interests: innate immunity; host susceptibility; healthcare management; biotechnology; climate neutral technology; bioresource sustainability
Department of Neonatology, Heidelberg University Children’s Hospital, Heidelberg, Germany
Interests: innate immunity; microglia; neutrophils; trained immunity; signaling; metabolism; epigenetics; endotoxin tolerance; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gaining insight into immunogenetic regulations is critical to further our understanding of the operation of the immune system at the molecular and cellular levels, devise personalized medicine strategies, and develop vaccines and therapies that are more efficacious against a wide range of immune-related ailments. Immune-related genes, population diversity and the environment may influence the disease susceptibility and immune responses through cytokines, receptors and additional components of the immune system. To reduce drug immunogenicity in emerging infectious, chronic and lifestyle diseases, and to understand host–pathogen interactions, it is important to understand the immune evasion and survival strategies of pathogens, host susceptibility, epigenetic regulators, modulators and inflammation.

Immunogenetics is useful for understanding of the basic mechanisms involved in diagnosis, therapeutics, immune tolerance, immune surveillance, major innate immune cell types, such as macrophages and neutrophils, and adaptive immune cell types, such as T lymphocytes and B lymphocytes, as well as the lymphatic system in disease conditions. For the anatomical, physiological, physiological, environmental and epidemiological statistical studies covered in this issue, contributions to knowledge of the genetic and epigenetic factors affecting immunity, intraspecific diversity, inheritance of tissue antigen and tissue compatibility through molecular-, cellular- and organ-level studies are welcome. This Special Issue features contributions to the field that enable in-depth research on drug effects and the mechanisms underlying disease progression, including advances in clinical biomarkers, regenerative medicine, microscopic techniques, heterologous gene expression, organ transplantation and multi-omics profiles. This Special Issue focuses on immune systems and their relationships to innovation, emerging technologies, natural medicine and the environment in order to present conceptual and practical advances regarding the state-of-the-art research on molecular and cellular mechanism. In order to create methods for early disease detection, real-time monitoring and prevention, it is intended to promote interest and research in this fascinating area.

Dr. Anshuman Mishra
Dr. Trim Lajqi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunity
  • host susceptibility
  • gene expression
  • biotechnology
  • disease resistance
  • immunogenicity
  • drug monitoring
  • vaccines
  • adaptive immunity

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

21 pages, 4216 KB  
Article
Bulk RNAseq Analysis of Cardiac Myosin-Specific CD4+ and CD8+ T Cells Reveals Distinct Transcriptomic Profiles Between Myocarditis-Resistant and Susceptible Mice
by Shraddha Singh, Meghna Sur, Kiruthiga Mone, Celia Wafa Ayad, Chandirasegran Massilamany, Arunakumar Gangaplara and Jay Reddy
Biomedicines 2025, 13(11), 2725; https://doi.org/10.3390/biomedicines13112725 - 6 Nov 2025
Viewed by 597
Abstract
Background: We recently generated T cell receptor (TCR) transgenic (Tg) mice specific to cardiac myosin heavy chain-α (Myhc-α 334–352) on both myocarditis-resistant (C57BL/6) and susceptible (A/J) genetic backgrounds. We noted that the antigen-specific TCRs were expressed in CD4+ and CD8+ [...] Read more.
Background: We recently generated T cell receptor (TCR) transgenic (Tg) mice specific to cardiac myosin heavy chain-α (Myhc-α 334–352) on both myocarditis-resistant (C57BL/6) and susceptible (A/J) genetic backgrounds. We noted that the antigen-specific TCRs were expressed in CD4+ and CD8+ T cells in both strains, but their responses differed. While the T cells from naïve Tg C57BL/6 mice do not respond to Myhc-α 334–352, whereas those from A/J mice spontaneously respond to the antigen, suggesting their underlying molecular mechanisms might differ. Methods: To investigate the mechanisms of differences in the antigen-responsiveness between the Tg C57BL/6 and A/J mice, we performed bulk RNA sequencing on CD4⁺ and CD8⁺ T cells sorted by flow cytometry. Differentially expressed genes, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, gene set enrichment analysis (GSEA) of GO and KEGG, and transcription factor (TF) network analyses were performed to identify pathways and regulators of immune responses. Results: First, the principal component analysis of the transcriptomic profiles distinguished CD4+ from CD8+ T cells, which also differed between the two strains. Second, the differentially expressed cytokine and cytotoxicity genes revealed similar patterns between CD4+ and CD8+ T cells. Importantly, KEGG enrichment analysis revealed downregulated pathways in both CD4+ and CD8+ T cells that are associated with viral myocarditis, and various autoimmune conditions in C57BL/6 as compared to A/J mice. Similarly, the GSEA of GO revealed negative regulation of heart contraction and positive regulation of cardiac muscle hypertrophy processes were negatively enriched in CD4+ T cells of C57BL/6 mice. Finally, by generating the transcription factor (TF) networks, 22 TFs were found common to both CD4+ and CD8+ T cells, whereas eight TFs were unique to CD4+ or CD8+ T cells that have a role in T cell activation, tolerance, and T regulatory cells. Conclusions: Our data provide new insights into the transcriptomic profiles that may contribute to the genetic resistance mechanisms for developing cardiac autoimmunity. Full article
(This article belongs to the Special Issue Immunogenetic Regulations for Disease Prognosis)
Show Figures

Figure 1

Back to TopTop