Advances in Therapeutic Strategies in Gynecological Malignant Tumors—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1047

Special Issue Editor


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Guest Editor
IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-IRST S.r.l, 47014 Meldola, Italy
Interests: gynecologic malignancies; urogenital carcinomas; breast cancer; predictive biomarkers; DNA repair deficiency; tumor molecular profiling; immune microenvironment; cardio-oncology
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Special Issue Information

Dear Colleagues,

In recent years, new insights, novel developments, novel discoveries, and future challenges have radically changed the field of gynecologic oncology.
According to tumor origin, gynecologic malignancies are mainly classified into ovarian cancer (epithelial, germ cell tumor, sexual-stromal tumor, and others), endometrial cancer, cervical cancer, and vulvar cancer, which are recognized as global health threats for women. Over recent decades, multimodal strategies consisting of surgery, radiation, and chemotherapy have been the main choices for the treatment of patients with gynecologic malignancies.
This research topic aims at providing updates on newly identified molecular targets and developed therapeutic strategies for gynecological cancers. It also aims to facilitate the discussion of recent advances in the screening, diagnosis, therapies, and prognosis of gynecological cancers. We welcome article submissions that provide novel information in the fields encompassing, but not limited to, the identification of cancer signaling pathways, potential therapeutic target discoveries, and the development of new targeted drugs and therapeutic strategies for gynecological cancers. These will help to highlight current knowledge in this research area as well as of trends in the targeted therapy of gynecological cancers.

Subtopics of interests include, but are not limited to, the following:

  • Identifications of novel biomarkers for diagnosis, therapies, or prognosis for different types of gynecological cancers.
  • Combinational therapeutic strategies (chemotherapy, immunotherapy, targeted agents, and radiotherapy) for gynecological cancers.
  • Treatment resistance strategies and mechanisms of gynecological cancers and corresponding potential therapies.
  • Novel drugs for gynecological cancers.

Dr. Alberto Farolfi
Guest Editor

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Keywords

  • targeted therapy
  • precision medicine
  • gynecological cancers
  • ovarian cancer
  • endometrial cancer
  • cervical cancer

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Published Papers (1 paper)

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Research

13 pages, 1341 KiB  
Article
Risk of Cervical Carcinoma After Unfavorable Behavior and High Genetic Risk in the UK Biobank: A Prospective Nested Case–Control Study
by Shiyi Liu, Yunlong Guan, Shitong Lin, Peng Wu, Qing Zhang, Tian Chu and Ruifen Dong
Biomedicines 2025, 13(2), 464; https://doi.org/10.3390/biomedicines13020464 - 13 Feb 2025
Viewed by 736
Abstract
Background: Previous studies have established a general understanding of the association between risky sexual behavior, genetic risk, and cervical carcinoma. However, these studies were conducted several years ago and lack systematic analysis using high-quality and population-based data. Methods: We conducted a [...] Read more.
Background: Previous studies have established a general understanding of the association between risky sexual behavior, genetic risk, and cervical carcinoma. However, these studies were conducted several years ago and lack systematic analysis using high-quality and population-based data. Methods: We conducted a prospective nested case–control study to identify risky behaviors and developed a behavior score. Combining the behavior score and genetic risk, we evaluated the effect of sexual and reproductive behavior and PRS on cervical carcinoma through the developed conditional logistic regression models. Results: We verified increased carcinoma risk in individuals with early sexual intercourse (OR: 1.41 [95% CI 1.09 to 1.83], p = 0.0083), non-monogamous sexual partners (OR: 3.13 [95% CI 2.15 to 4.57], p < 0.0001), three or more live births (OR: 1.44 [95% CI 1.12 to 1.84], p = 0.0040), and high PRS (polygenic risk score) (top 25% of PRS, OR: 1.58 [95% CI 1.15 to 2.16], p = 0.0044). The unfavorable sexual and reproductive behavior score we developed was linked to a 151% increased risk (OR: 2.51 [95% CI 1.79 to 3.52], p < 0.0001) after adjusting for PRS. Women with both unfavorable behavior and high genetic risk had a 5.5-fold increased cervical carcinoma risk (OR: 5.45 [95% CI 2.72 to 10.95], p < 0.0001) compared to individuals with favorable behavior and low genetic risk. Conclusions: Unfavorable sexual and reproductive behavior increases the risk of cervical carcinoma, especially in those with a high genetic risk. These findings encourage us to adhere to a healthy sexual and reproductive pattern. Full article
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