Vitamin K and Vitamin D in Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 567

Special Issue Editors


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Guest Editor
Department of Biochemistry, University of Medicine and Pharmacy Iuliu Hatieanu Cluj-Napoca, Cluj-Napoca, Romania
Interests: bone metabolism; vitamin D; biomedical science; cartilage arthritis; rheumatoid arthritis; bone; osteoblasts; vitamin K; atherosclerosis; bone research; clinical chemistry; clinical trials; nutritional biochemistry; bone mineral density; osteoporosis; cardiovascular risk; hip fracture; bone mineralization; myocardial infarction; calcium; metabolic syndrome; lipids; lipoproteins; cardiovascular disease; diabetes; chronic inflammation; chronic intestinal disease; microbiota; short-chain fatty acids
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Guest Editor
Department of Medical Biochemistry, University of Medicine and Pharmacy Iuliu Hatieanu Cluj-Napoca, Cluj-Napoca, Romania
Interests: vitamin K-dependent proteins; atherosclerosis; clinical chemistry; ectopic calcifications; cardiovascular and renal diseases; metabolic syndrome; diabetes mellitus; chronic and acute inflammation; chronic bowel diseases; microbiota; short-chain fatty acids

Special Issue Information

Dear Colleagues,

The liposoluble vitamins D and K are well known to play roles in multiple processes, from calcium metabolism to immunity, to energy metabolism and cancer prevention. This Special Issue will focus on the role of vitamin D- and K-dependent proteins in diseases associated with metabolic or endocrine disbalances. In addition to providing insights into the vitamin D and K status in healthy subjects and diseases, this Special Issue will pay special attention to the regulatory effects of short-chain fatty acids, as products of the gut microbiota, on serum vitamin K-dependent proteins. Researchers are invited to share their knowledge and expertise regarding their recent research observations in this field.

Prof. Dr. Alexandra M. Crăciun
Dr. Ciprian N. Silaghi
Guest Editors

Manuscript Submission Information

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Keywords

  • vitamin D
  • vitamin K
  • Gla proteins
  • cardiovascular and renal diseases
  • metabolic syndrome
  • diabetes mellitus
  • chronic and acute inflammation
  • chronic bowel diseases
  • cartilage arthritis
  • rheumatoid arthritis
  • osteoblasts
  • bone research
  • atherosclerosis
  • lipids
  • lipoproteins
  • short-chain fatty acids.

Published Papers (1 paper)

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Research

12 pages, 564 KiB  
Article
Low Vitamin K Status in Patients with Psoriasis Vulgaris: A Pilot Study
by Simona R. Gheorghe, Tamás Ilyés, Gabriela A. Filip, Ana S. Dănescu, Teodora L. Timiș, Meda Orăsan, Irina Stamate, Alexandra M. Crăciun and Ciprian N. Silaghi
Biomedicines 2024, 12(6), 1180; https://doi.org/10.3390/biomedicines12061180 - 26 May 2024
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Abstract
Psoriasis vulgaris (PV) is a disease characterized by skin manifestations and systemic inflammation. There are no published studies to date on vitamin K status assessed by extrahepatic vitamin K-dependent proteins [e.g., osteocalcin (OC) and matrix Gla protein (MGP)] in patients with PV, even [...] Read more.
Psoriasis vulgaris (PV) is a disease characterized by skin manifestations and systemic inflammation. There are no published studies to date on vitamin K status assessed by extrahepatic vitamin K-dependent proteins [e.g., osteocalcin (OC) and matrix Gla protein (MGP)] in patients with PV, even if vitamin K was found to promote wound contraction and decrease the healing time of the skin. Metabolic syndrome (MS), a comorbidity of PV, was found to influence vitamin K status, and vitamin D was found to be involved in the pathogenesis of PV. Therefore, our aim was to assess the status of vitamins K and D in subjects with PV. We enrolled 44 patients with PV and 44 age- and sex-matched subjects as a control group (CG), of which individuals with MS were designated the CG with MS subgroup. Furthermore, the PV patients were stratified into two subgroups: those with MS (n = 20) and those without MS (n = 24). In addition to the quantification of vitamin D and MGP in all subjects, the uncarboxylated OC/carboxylated OC (ucOC/cOC) ratio was also assessed as an inversely proportional marker of vitamin K status. We found an increased ucOC/cOC ratio in the PV group compared to CG but also a greater ucOC/cOC ratio in the PV with MS subgroup than in the CG with MS subgroup. MGP was decreased in the PV with MS subgroup compared to CG with MS subgroup. There was no difference in the vitamin D concentration between the groups. This is the first study to report decreased vitamin K status in patients with PV, independent of the presence of MS. Full article
(This article belongs to the Special Issue Vitamin K and Vitamin D in Health and Disease)
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