Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.8
3.9
Journals
Biomedicines
Special Issues
Advances in Stroke Neuroprotection and Repair
share announcement

Advances in Stroke Neuroprotection and Repair

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 450

Special Issue Editor

Dr. Konstantinos Tsamakis

E-Mail Website
Guest Editor
Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Interests: mental health; depression; anxiety; gut microbiome; dementia; psychosis; psychopharmacology; COVID-19
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stroke, a leading cause of morbidity and mortality globally, poses a significant burden on healthcare systems and individual lives. Despite advances in prevention, management, and rehabilitation strategies, the devastating consequences of stroke, particularly the irreversible damage to the brain, continue to challenge the medical community. This Special Issue “Advances in Stroke Neuroprotection and Repair”, aims to bring together the latest research advancements that are aimed at mitigating the harmful effects of stroke and promoting neural repair and recovery.

This Special Issue will investigate novel therapeutic targets and approaches to interrupt the cascade of events that lead to neuronal death following stroke. These include, but are not limited to, the modulation of inflammatory responses, the restoration of blood flow and oxygen supply to the affected brain regions, and the promotion of neural regeneration and plasticity. Furthermore, given the intricate interplay between blood vessels and neural tissue in the brain, research on angiogenesis and its role in stroke recovery will also be highlighted.

This Special Issue also aims to provide a platform for researchers to share their insights into the complex pathophysiology of stroke, including the role of oxidative stress, inflammation, and other biological processes that contribute to neuronal damage. By bringing together experts from diverse fields, we hope to foster interdisciplinary collaboration and accelerate the translation of basic research findings into clinical practice.

Dr. Konstantinos Tsamakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • cerebral infarction
  • neuronal damage
  • neural regeneration
  • neuroprotection

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 1204 KiB  
Article
Effectiveness and Safety of Endovascular Treatment in Large Vessel Occlusion Stroke with an NIHSS Score of ≤5 Exhibiting Predominant Cortical Signs
by Chulho Kim, Seung Joon Oh, Jae Jun Lee, Jong-Hee Sohn, Joo Hye Sung, Yerim Kim, Minwoo Lee, Mi Sun Oh, Kyung-Ho Yu, Hee Jung Mo and Sang-Hwa Lee
Biomedicines 2025, 13(7), 1700; https://doi.org/10.3390/biomedicines13071700 - 11 Jul 2025
Viewed by 185
Abstract
Background: Our study aimed to evaluate the impact of EVT on stroke outcomes in patients with LVO with a National Institute of Health Stroke Scale (NIHSS) score of ≤5, exhibiting primarily cortical signs. Methods: We conducted a multicenter registry-based analysis of [...] Read more.
Background: Our study aimed to evaluate the impact of EVT on stroke outcomes in patients with LVO with a National Institute of Health Stroke Scale (NIHSS) score of ≤5, exhibiting primarily cortical signs. Methods: We conducted a multicenter registry-based analysis of patients with acute ischemic stroke with LVO who arrived within 12 h of onset. Among these, patients with low NIHSS scores and prominent cortical signs (Items 2, 3, 9, or 11) were included. Patients were divided into two groups: those who underwent EVT and those treated with the best medical therapy (BMT), which included intravenous thrombolysis where appropriate. The primary outcome measure was a modified Rankin scale (mRS) score of 0–1 at 3 months and symptomatic hemorrhagic transformation (SHT). We performed logistic regression analysis to evaluate the impact of EVT on the outcomes. Results: Of the 970 patients with LVO, 291 met the inclusion criteria, with 95 and 196 undergoing EVT and BMT, respectively. The EVT group demonstrated a significantly higher rate of 3-month mRS score of 0–1 (65.3% vs. 39.3%, p < 0.001) and a lower incidence of SHT than the BMT group (3.2% vs. 12.8%, p = 0.01). Multivariate analysis confirmed that EVT was associated with improved functional recovery (mRS score, 0–1; odds ratio [OR], 3.61; 95% confidence interval [CI], 1.82–7.06; p < 0.001) and reduced risk of SHT (OR, 0.19; 95% CI, 0.05–0.74; p = 0.02). Notably, patients with specific cortical signs, such as aphasia and spatial neglect, exhibited better outcomes with EVT. Conclusions: EVT may significantly improve the functional outcomes in patients with mild LVO stroke who present with cortical signs, despite low NIHSS scores. These findings suggest that cortical signs should be a key factor in EVT decision-making for mild stroke cases, thereby advocating for a more individualized approach in acute stroke management. Full article
(This article belongs to the Special Issue Advances in Stroke Neuroprotection and Repair)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop