Gastric Cancer: Molecular and Translational Aspects on Carcinogenesis and Treatment

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 627

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Interests: gastric cancer; hepato-pancreato-biliary system; digestive disorders; pancreatic cancer
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Special Issue Information

Dear Colleagues,

Gastric cancer is one of the most aggressive cancers. Over the last decade, we have observed a decline in the incidence of gastric cancer; however, no record-breaking progress in its treatment has been made. This Special Issue will focus on understanding the molecular mechanisms of gastric cancer, the crosstalk of cancer cells with their microenvironment, and the potential therapeutic vulnerabilities. We invite authors to submit original research and review articles that focus on basic and translational research relating to gastric cancer and various new and powerful technologies. The goal is to stimulate research and clinical interest in developing strategies for the prediction, prevention, diagnosis, and treatment of gastric cancer to finally improve the treatment outcomes in patients with this malignant disease.

Dr. Sharona B. Ross
Guest Editor

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Keywords

  • gastric cancer
  • tumor microenvironment
  • molecular mechanism
  • targeted therapy

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Published Papers (1 paper)

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Research

18 pages, 1592 KB  
Article
Exploratory Insights into Gastric Cancer Metabolism Through Amino Acid and Acylcarnitine Profiling in Plasma Samples
by Ștefan Ursu, Cristina-Paula Ursu, Luisa-Gabriela Bogos, Ioana-Ecaterina Pralea, Radu-Cristian Moldovan, Florin Zaharie, Zeno Spârchez, Răzvan Alexandru Ciocan, Rodica Sorina Pop, Cătălin Ioan Bodea, Claudia Diana Gherman, Cristina-Adela Iuga and Nadim Al Hajjar
Biomedicines 2025, 13(9), 2220; https://doi.org/10.3390/biomedicines13092220 - 10 Sep 2025
Viewed by 498
Abstract
Background: Gastric cancer ranks fifth among the most prevalent malignancies, with poor prognosis due to limited early-stage diagnosis. Metabolic reprogramming plays a central role in GC development, sustaining carcinogenic processes. Methods: In this study, flow-injection tandem mass spectrometry was used to [...] Read more.
Background: Gastric cancer ranks fifth among the most prevalent malignancies, with poor prognosis due to limited early-stage diagnosis. Metabolic reprogramming plays a central role in GC development, sustaining carcinogenic processes. Methods: In this study, flow-injection tandem mass spectrometry was used to analyse plasma amino acids and acylcarnitines in 62 gastric cancer patients and 70 healthy individuals. Metabolic profiles were correlated with clinical parameters, tumour histology, and recurrence. Results: Gastric cancer patients showed significantly reduced levels of Trp, Arg, Tyr, Met, and sum of aromatic AAs—metabolites usually implicated in supporting tumour cell growth and proliferation. At the same time, elevated unsaturated, hydroxylated, and dicarboxylic acylcarnitines suggest mitochondrial and peroxisomal dysfunction. Marked metabolic heterogeneity was observed across histological subtypes, with the indeterminate subtype exhibiting the most pronounced disruption in fatty acid oxidation and widespread acylcarnitine alterations. Decreased levels of C6DC-carnitine and Cit synthesis were correlated with higher tumour recurrence, warranting further confirmatory investigations. Conclusions: These findings underscore the value of plasma profiling of amino acids and acylcarnitines for understanding gastric cancer biology, revealing distinct metabolic adaptations reflecting tumour biology, histological subtype, and treatment response. Full article
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