Past, Present and Further Looking for Therapeutic Management of Pancreatic Ductal Adenocarcinoma (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 215

Special Issue Editors


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Guest Editor
1. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy
2. Pancreatic Surgery Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy
Interests: pancreatic cancer; periampullary tumors; ampullary carcinoma; general surgery; pancreatectomy; pancreatic surgery
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Guest Editor
Cancer Pharmacology Lab, AIRC Start-Up Unit, Fondazione Pisana per la Scienza ONLUS, 56017 Pisa, Italy
Interests: pancreatic cancers; pancreatic ductal adenocarcinoma; IPMN; histopathology; primary cell cultures; molecular biology; molecular pathology; laser microdissection; miRNAs; oncomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pancreatic ductal adenocarcinoma (PDAC) still represents one of the cancers with the poorest prognosis. Currently, surgery remains the only curative treatment for PDAC, but the 5-year survival rate of resected patients is only about 20–25%. During the last decades, some improvements have been achieved in terms of chemotherapic treatment, with the development of specific multi-chemotherapic regimens (FOLFIRINOX, gemcitabine + nab-paclitaxel, PAX-G) that have improved oncological results if compared with historically adopted single chemotherapic agents (gemcitabine). Moreover, if historically, for resectable PDAC, the gold standard strategy was surgery followed by adjuvant therapy, currently the scenario is radically changing. More often, the idea is to perform neoadjuvant therapy followed by surgery and, eventually, adjuvant treatment. The rationale for this approach is the early management of micro-metastatic disease and to allow a better selection of patient candidates for surgery. Thus, the analyses of old, recent, and upcoming molecular markers could change the landscape of clinical management of the PDAC. However, preclinical models of PDAC, including all different levels of models approaching PDAC, will be appreciated in order to show experimental attempts to validate the role of biomolecular markers and their affinity for chemotherapy. Indeed, other new frontiers of PDAC treatment, including phytotherapy and theragnostic molecules, are welcome.

This Special Issue aims to evaluate all the novel therapeutic approaches for the management of PDAC (resectable, borderline-resectable, locally advanced, and metastatic disease). Pre-clinical and clinical studies focusing on this topic will be included in this Special Issue.

Dr. Gennaro Nappo
Dr. Niccola Funel
Guest Editors

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Keywords

  • pancreatic cancer
  • pancreatic ductal adenocarcinoma
  • treatment pancreatic cancer
  • chemotherapy pancreatic cancer
  • radiotherapy pancreatic cancer
  • pancreatic cancer biology
  • PDAC preclinical model
  • biomolecular markers
  • theragnostic molecules
  • target therapy

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Published Papers (1 paper)

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Research

21 pages, 5044 KiB  
Article
Unraveling the Pancreatic Anlagen: Validating a Manual Dissection Protocol with Immunohistochemical Staining for Pancreatic Polypeptide in a Human Cadaver Study
by Athanasios Alvanos, Elisa Schubert, Karsten Winter and Hanno Steinke
Biomedicines 2025, 13(6), 1318; https://doi.org/10.3390/biomedicines13061318 - 28 May 2025
Abstract
Background: The pancreas develops from two independent buds that fuse to form the adult organ. Ontogeny has largely been neglected in pancreatic surgery. This study aims to demonstrate that the adult pancreas can still be divided into morphogenetic units based on its [...] Read more.
Background: The pancreas develops from two independent buds that fuse to form the adult organ. Ontogeny has largely been neglected in pancreatic surgery. This study aims to demonstrate that the adult pancreas can still be divided into morphogenetic units based on its embryological compartments and connective tissue borders for potential therapeutic purposes. Methods: Ten donor bodies (four female, six male, aged 73–101 years) were used. Manual dissection, guided by the common bile duct to locate the embryological fusion plane, was performed to divide the pancreatic tissue. Immunohistochemical staining for pancreatic polypeptide differentiated the pancreatic tissue by embryological origin and was used to quantify dissection accuracy. Results: Landmark-guided dissection successfully separated the pancreas along a connective tissue plane in seven cases. The resulting compartments were distinctly divided along the dissection plane into an area rich in pancreatic polypeptide and an area with low accumulation. Two cases showed deviations from the dissection plane at the histological level. One case contained tumor tissue, interfering with the utilization of landmarks. Conclusions: Landmark-guided dissection of the pancreas based on its embryological fusion plane allows for reliable separation into morphogenetic compartments. Immunohistochemical staining for pancreatic polypeptide effectively differentiates tissue origins. This approach may enable more precise, differentiated pancreatic resections and tailored treatments, with potential for refinement in routine surgical practice. Approaching the pancreatic tissue with regard to its ontogenetic origin and its clearly distinguishable compartments might even enable tailored treatment beyond refined surgical procedures. Full article
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