Bone Metabolism in Health and Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 513
Editor
Special Issue Information
Dear Colleagues,
Bone is a dynamic tissue that undergoes constant remodeling through the coordinated actions of bone-resorbing osteoclasts and bone-forming osteoblasts, supported by skeletal stem/progenitor cells and the bone marrow microenvironment. Bone metabolism is crucial not only for maintaining skeletal integrity but also for regulating mineral homeostasis and systemic health. The dysregulation of bone metabolic processes contributes to a wide spectrum of disorders, including osteoporosis, osteoarthritis, fracture non-union, metabolic bone diseases, and bone loss associated with aging and chronic conditions. With populations aging worldwide, bone-related diseases represent an increasing global health burden, underscoring the urgent need to deepen our understanding of the mechanisms underlying bone metabolism and to develop novel therapeutic approaches.
This Special Issue aims to highlight recent advances in the molecular, cellular, and translational aspects of bone metabolism in both health and disease contexts. We invite original research articles, reviews, and perspectives that provide new insights into the regulation of bone turnover, signaling pathways governing skeletal homeostasis, and therapeutic strategies targeting bone metabolic disorders. The scope is broad yet focused, aligning with the journal’s mission to cover the clinically and biologically relevant aspects of bone and musculoskeletal health.
In this Special Issue, original research articles and reviews are welcome. Research areas may include but are not limited to the following:
- Mechanisms of bone remodeling and skeletal stem/progenitor cell biology, including the roles of osteoblasts, osteoclasts, and osteocytes;
- Molecular and cellular pathways regulating osteogenesis, osteoclastogenesis, and osteoimmunology;
- Bone metabolism in aging, endocrine disorders, chronic inflammation, and diseases;
- Osteocylic regulation on bone homeostasis and diseases;
- Genetic and epigenetic regulation of bone homeostasis;
- Biomarkers for diagnosis, prognosis, and monitoring of bone metabolic diseases;
- Preclinical and clinical evaluation of pharmacological, biological, and cell-based therapies;
- Crosstalk between bone and other organ systems in health and disease;
- Novel technologies in bone biology, including omics, imaging, and spatial transcriptomics.
We look forward to receiving your contributions and advancing the field together.
Sincerely,
Dr. Kun Chen
Guest Editor
Manuscript Submission Information
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Keywords
- bone remodeling
- skeletal stem cells
- osteocyte
- osteoblasts
- osteoclasts
- osteoporosis
- osteoarthritis
- bone regeneration
- bone aging
- bone therapeutics
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