Poly-Pharmacological Effects and Mechanisms of Phytochemicals

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 760

Special Issue Editor


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Guest Editor
School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA
Interests: poly-pharmacology; metabolic syndrome; gut microbiota

Special Issue Information

Dear Colleagues,

Phytochemicals hold immense potential for developing treatments for various diseases, as evidenced by compounds like artemisinin, celastrol, and berberine. Their poly-pharmacological properties, which allow them to target multiple diseases, have garnered growing interest. For example, while artemisinin was initially used to treat malaria and helminth infections, recent research has demonstrated its potential for treating liver diseases, neurological disorders, immune dysfunctions, and cancer. This versatility raises important questions: Are there more undiscovered uses for these compounds, and what makes them so broadly effective?

We invite researchers and authors in this field to contribute original research or review articles for this Special Issue. The goal is to showcase the vast array of bioactive compounds (with defined molecular compound) derived from natural sources and their critical role in modern drug discovery. Submissions focusing on novel applications of phytochemicals, the mechanisms underlying their poly-pharmacological effects, and updates on well-studied compounds are highly encouraged.

Dr. Jiawen Shou
Guest Editor

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Keywords

  • phytochemicals
  • natural products
  • poly-pharmacology
  • novel application
  • research updates on phytochemicals

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Published Papers (1 paper)

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Review

37 pages, 2862 KB  
Review
Exploring the Benefits of Cranberries in Dentistry: A Comprehensive Review
by Isabella Schönhofen Manso, Yasmim Guterres Bauer, Eduarda Blasi Magini, Gabriel Leonardo Magrin, Izabella Thais da Silva and Ariadne Cristiane Cabral Cruz
Biomedicines 2026, 14(1), 85; https://doi.org/10.3390/biomedicines14010085 - 31 Dec 2025
Viewed by 425
Abstract
Objectives: Despite the increasing scientific evidence regarding the application of Cranberries in dentistry, a comprehensive understanding of their potential benefits, active constituents, and mechanisms of action remains lacking. Consequently, this narrative review aims to meticulously analyze and consolidate the existing scientific literature on [...] Read more.
Objectives: Despite the increasing scientific evidence regarding the application of Cranberries in dentistry, a comprehensive understanding of their potential benefits, active constituents, and mechanisms of action remains lacking. Consequently, this narrative review aims to meticulously analyze and consolidate the existing scientific literature on the utilization of Cranberries for the prevention and treatment of oral diseases. Materials and Methods: Electronic databases (PubMed, Scopus, and Web of Science) were searched up to October 2025. This review included in vitro, in vivo, and clinical research studies. A two-phase selection process was carried out. In phase 1, two reviewers independently screened titles and abstracts to identify potentially eligible studies. In phase 2, the same reviewers performed the full-text assessments of the eligible articles. Results: Among the 93 eligible articles, most assessed Cranberry use in Cariology (n = 28) and Periodontics (n = 26). Biofilm and microbial virulence factors (n = 46) were the most frequently studied topics. Cranberry extract (n = 32) and high-molecular-weight non-dialyzable material (NDM) (n = 23) were the most evaluated Cranberry fractions. Overall, Cranberry-derived compounds were identified as non-toxic and demonstrated promising antimicrobial activity against dental caries-related microorganisms in preclinical studies (n = 20). Regarding periodontal and peri-implant diseases, Cranberry demonstrated host immune modulator effects, counteracting the inflammatory and destructive mechanisms (n = 8). Additionally, Cranberries presented benefits in reducing the inflammation associated with periodontal disease and temporal mandibular joint lesions (n = 1). Regarding dental erosion, Cranberry inhibited dentin erosion (n = 4); however, no effect was observed on enamel lesions (n = 2). As an antioxidant agent, Cranberry showed effectiveness in preventing dental erosion (n = 18). Beyond that, Cranberry neutralized reactive oxygen species generated immediately after dental bleaching, enhancing bond strength (n = 2) and counteracting the oxygen ions formed on the tooth surface following bleaching procedures (n = 3). In osteoclastogenesis assays, A-type proanthocyanidins inhibited bone resorption (n = 1). In osteogenic analysis, preservation of hydroxycarbonate apatite deposition and an increase in early and late osteogenic markers were observed (n = 2). Conclusions: Cranberry bioactive compounds, both individually and synergistically, exhibit substantial potential for diverse applications within dentistry, particularly in the prevention and management of oral and maxillofacial diseases. This review provides insights into the plausible incorporation of Cranberries in contemporary dentistry, offering readers an informed perspective on their potential role. Full article
(This article belongs to the Special Issue Poly-Pharmacological Effects and Mechanisms of Phytochemicals)
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