Bone Diseases: Pathophysiology and Molecular Biology

Dear Colleagues,

Bone diseases represent a significant global health challenge, affecting millions of people and leading to debilitating conditions that impact quality of life. Understanding the intricate pathophysiology and molecular biology underlying these diseases is crucial for advancing diagnosis, treatment, and prevention strategies. Over the past decades, extensive research has shed light on the complex interactions between genetic, environmental, and cellular factors that contribute to disorders such as osteoporosis, osteoarthritis, Paget’s disease, and bone tumors. Despite this progress, numerous gaps remain in our understanding of the molecular mechanisms that govern bone homeostasis and disease progression.

This Special Issue aims to bring together the latest advancements in the study of bone diseases, focusing on the molecular and cellular mechanisms that drive these conditions. Contributions will explore a broad spectrum of topics, from genetic mutations to signaling pathways, inflammation, and the role of the bone microenvironment. A particular emphasis will be placed on the diagnostic and prognostic implications of these findings. Understanding the molecular underpinnings of bone diseases has the potential to not only enhance early detection and risk stratification but also guide the development of personalized therapeutic approaches and improve patient outcomes.

Dr. Tommaso Greco
Dr. Carlo Perisano
Dr. Nicola De Gasperis
Guest Editors

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